{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:20:52Z","timestamp":1766269252764},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T00:00:00Z","timestamp":1428451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Our aim was to determine factors that affect maternal serum magnesium (Mg) levels, to help ensure the safety and efficacy of long\u2010term magnesium sulfate (MgSO<jats:sub>4<\/jats:sub>) therapy for threatened preterm labor in singleton and twin pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>We retrospectively and arbitrarily studied 100 patients (singleton pregnancy, <jats:italic>n<\/jats:italic> = 65; twin pregnancy, <jats:italic>n<\/jats:italic> = 35) who received i.v. MgSO<jats:sub>4<\/jats:sub> for &gt;48 h for tocolysis of threatened preterm labor. We used multiple regression analysis to investigate the functional relations between the candidate factors and maternal serum Mg levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MgSO<jats:sub>4<\/jats:sub> was administered as a loading dose of 3 g for 1\u2009h followed by a maintenance dose of 1.0\u20132.0 g\/h. There were no maternal severe adverse events related to the elevated Mg levels in any of the subjects. The results of multiple regression analysis revealed that total dose of MgSO<jats:sub>4<\/jats:sub> for 24 h before blood collection (g\/day), total serum protein level (g\/dL), serum total calcium level (mg\/dL), serum creatinine level (mg\/dL) and maternal bodyweight (kg) significantly affected maternal serum Mg levels in both singleton and twin pregnancies (all <jats:italic>P<\/jats:italic>\u2010values were &lt; 0.001). Gestational age (weeks) and period of MgSO<jats:sub>4<\/jats:sub> administration (days) at blood collection had no significant effect in singleton or twin pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study statistically shows that dose of MgSO<jats:sub>4<\/jats:sub>, total serum protein level, serum total calcium level, serum creatinine level and maternal bodyweight are key factors to achieving safe and effective long\u2010term tocolysis with MgSO<jats:sub>4<\/jats:sub> in not only singleton but also twin pregnancies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12690","type":"journal-article","created":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T10:02:29Z","timestamp":1428487349000},"page":"1178-1184","source":"Crossref","is-referenced-by-count":5,"title":["Factors affecting maternal serum magnesium levels during long\u2010term magnesium sulfate tocolysis in singleton and twin pregnancy"],"prefix":"10.1111","volume":"41","author":[{"given":"Hiroshi","family":"Nakazawa","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Perinatal Medical Center Hyogo Prefectural Kobe Children's Hospital  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Perinatal Medical Center Hyogo Prefectural Kobe Children's Hospital  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Minamitani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Perinatal Medical Center Hyogo Prefectural Kobe Children's Hospital  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Makishi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Perinatal Medical Center Hyogo Prefectural Kobe Children's Hospital  Kobe 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