{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T01:16:09Z","timestamp":1771463769904,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T00:00:00Z","timestamp":1431648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to compare the hemodynamic profile and efficacy of carbetocin versus intra\u2010umbilical oxytocin in the management of retained placenta following vaginal delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>In this randomized clinical study, women with retained placenta for more than 30\u2009min were assigned to receive either an i.v. bolus of 100\u2010\u00b5g carbetocin (<jats:italic>n<\/jats:italic> = 38) or an intra\u2010umbilical vein injection of 50\u2009IU oxytocin in 30\u2009mL saline (<jats:italic>n<\/jats:italic> = 40). The main parameters evaluated were the success rate for expulsion of the placenta and the effects of these drugs on maternal blood pressure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The success rate in the carbetocin group was 86.84% compared to 77.5% in the intra\u2010umbilical oxytocin group. Notably, 57.7% of the participants had prior induction of labor or augmentation during labor. There were no significant differences between the two groups regarding the estimated blood loss, drop of hemoglobin within the first 48\u2009h, additional uterotonic injection or the need for manual removal of the placenta. Systolic blood pressure was significantly lower in the intra\u2010umbilical oxytocin group at 30 and 60\u2009min after injection (<jats:italic>P<\/jats:italic>\u2009=\u20090.008, 0.026, respectively). Nonetheless, diastolic blood pressure was significantly lower in the intra\u2010umbilical oxytocin group than in the carbetocin group at 30\u2009min (<jats:italic>P<\/jats:italic>\u2009=\u20090.036).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A single i.v. bolus of carbetocin and umbilical vein injection of 50\u2009IU oxytocin are similarly effective in reducing the need for manual removal of the placenta. Carbetocin seems to have an acceptable hemodynamic safety profile and can be used as an alternative choice to the conventional oxytocic agents in the management of retained placenta.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12702","type":"journal-article","created":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T10:33:41Z","timestamp":1431686021000},"page":"1207-1213","source":"Crossref","is-referenced-by-count":5,"title":["Carbetocin versus intra\u2010umbilical oxytocin in the management of retained placenta: A randomized clinical study"],"prefix":"10.1111","volume":"41","author":[{"given":"Amr K.","family":"Elfayomy","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Taibah University  Almadinah Almunawarah, Saudi Arabia"},{"name":"Department of Obstetrics and Gynecology Zagazig University  Zagazig, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2008.07.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2004.03.014"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e318265246a"},{"key":"e_1_2_7_5_1","first-page":"863","article-title":"Prolonged third stage of labour: morbidity and risk factors","volume":"77","author":"Combs CA","year":"1991","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000151993.83276.70"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2012.01974.x"},{"key":"e_1_2_7_8_1","first-page":"528","article-title":"Pharmacokinetics of carbetocin, a long acting oxytocin analogue, in nonpregnant women","volume":"47","author":"Sweeney G","year":"1990","journal-title":"Curr Ther Res"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01105.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719112468951"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1991.tb13423.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2007.05.007"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61752-9"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.02.013"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(12)90821-2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(00)00451-3"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(00)82763-0"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/638093"},{"key":"e_1_2_7_19_1","first-page":"572","article-title":"Estimation of blood loss during caesarean section: An audit","volume":"56","author":"Khan FA","year":"2006","journal-title":"J Pak Med Assoc"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1996.tb03273.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-009-0973-8"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d4661"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2009.02226.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2005.00681.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2011.03022.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1054\/ijoa.2002.0970"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/ael302"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq004"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12702","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12702","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.12702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T23:02:45Z","timestamp":1696460565000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.12702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,15]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/jog.12702"],"URL":"https:\/\/doi.org\/10.1111\/jog.12702","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,15]]}}}