{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:14:42Z","timestamp":1789769682953,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T00:00:00Z","timestamp":1431648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Maternal sepsis is one of the leading causes of maternal mortality around the world. The aim of this study was to estimate the incidence and mortality rate of sepsis, and the associated risk factors for their development during pregnancy, labor, delivery and the post\u2010partum period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a population\u2010based cohort study consisting of 5 million births that occurred in the USA. Data were obtained from the Healthcare Cost and Utilization Project\u2013Nationwide Inpatient Sample (HCUP\u2010NIS) database from 1998 to 2008. Logistic regression was used to calculate the adjusted odds ratio and corresponding 95% confidence intervals (95%CI) for sepsis development and sepsis\u2010related death during admission for delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall incidence of maternal sepsis was 29.4 per 100\u2009000 births (95%CI: 28.0\u201330.9) with a sepsis case fatality rate of 4.4 per 100 births (95%CI: 3.5\u20135.6). Both the incidence of maternal sepsis and sepsis\u2010related death rate have increased over the last decade. Women who are black, older than 35\u2009years and who smoke were more likely to experience maternal sepsis. An association was also found between maternal sepsis and diabetes mellitus, cardiovascular disease, eclampsia, preterm birth, hysterectomy, puerperal infection, post\u2010partum hemorrhage, transfusion and chorioamnionitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mortality from maternal sepsis during labor and delivery is an increasing and important problem in westernized countries. Initiatives aimed at improving early recognition and effective management may help reduce the occurrence and outcomes of maternal sepsis at time of labor and delivery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12710","type":"journal-article","created":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T10:33:59Z","timestamp":1431686039000},"page":"1201-1206","source":"Crossref","is-referenced-by-count":74,"title":["Incidence and risk factors of sepsis mortality in labor, delivery and after birth: Population\u2010based study in the USA"],"prefix":"10.1111","volume":"41","author":[{"given":"Ghassan","family":"Al\u2010Ostad","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Jewish General Hospital McGill University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Kezouh","sequence":"additional","affiliation":[{"name":"Centre for Clinical Epidemiology and Community Studies Jewish General Hospital  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea R.","family":"Spence","sequence":"additional","affiliation":[{"name":"Centre for Clinical Epidemiology and Community Studies Jewish General Hospital  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haim A.","family":"Abenhaim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Jewish General Hospital McGill University"},{"name":"Centre for Clinical Epidemiology and Community Studies Jewish General Hospital  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69380-X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68397-9"},{"key":"e_1_2_6_4_1","volume-title":"Healthcare Cost and Utilization Project (HCUP). 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