{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:09:34Z","timestamp":1760044174936},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T00:00:00Z","timestamp":1432512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the utility of recombinant activated Factor VII (rFVIIa) for severe post\u2010partum hemorrhage (PPH) in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 69 patients treated with rFVIIa for severe PPH; 44 patients were from the registry of Japan Society of Obstetrical, Gynecological and Neonatal Hematology, and 25 were identified by a survey of the Japan Society of Obstetrics and Gynecology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, the mean and median blood loss were 11\u2009835\u2009mL and 8639\u2009mL, respectively. Treatment before rFVIIa included transarterial embolization in 23 patients and hysterectomy in 38. Forty\u2010two patients had a single dose, 17 had two doses, and four had three doses. The mean (\u00b1 SD) single dose was 81.60\u2009\u00b1\u200916.25\u2009\u00b5g\/kg. Sixty\u2010five patients survived, and four died. The cause of PPH in patients who died was uterine rupture plus amniotic fluid embolism in two patients, uterine cervical laceration in one, and placental abruption in one. The amount of blood loss in cases of death was 6428\u201343\u2009810\u2009mL. This suggested that whether a patient survives or not was more dependent on her general condition before and after rFVIIa treatment than on the amount of blood loss. Four patients had thromboembolic events after rFVIIa treatment (deep vein thrombosis; deep vein thrombosis plus pulmonary embolism; acute myocardial infarction; and pulmonary embolism); all of these patients recovered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present promising results may support the utility of rFVIIa for severe PPH in Japan.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12712","type":"journal-article","created":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T23:58:18Z","timestamp":1432598298000},"page":"1161-1168","source":"Crossref","is-referenced-by-count":20,"title":["Experience with recombinant activated factor VII for severe post\u2010partum hemorrhage in Japan, investigated by Perinatology Committee, Japan Society of Obstetrics and Gynecology"],"prefix":"10.1111","volume":"41","author":[{"given":"Maki","family":"Murakami","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Aiwa Hospital  Kawagoe Saitama"},{"name":"Perinatology Committee Japan Society of Obstetrics and Gynecology  Tokyo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hamamatsu Medical Center  Hamamatsu"},{"name":"Perinatology Committee Japan Society of Obstetrics and Gynecology  Tokyo"},{"name":"Japan Society of Obstetrical Gynecological and Neonatal Hematology  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiko","family":"Kubo","sequence":"additional","affiliation":[{"name":"Division of Obstetrics, Center of Maternal\u2013Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development"},{"name":"Perinatology Committee Japan Society of Obstetrics and Gynecology  Tokyo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Hata","sequence":"additional","affiliation":[{"name":"Perinatology Committee Japan Society of Obstetrics and Gynecology  Tokyo"},{"name":"Department of Perinatology and Gynecology Kagawa University Graduate School of Medicine  Miki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Juntendo University Faculty of Medicine"},{"name":"Perinatology Committee Japan Society of Obstetrics and Gynecology  Tokyo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Masuzaki","sequence":"additional","affiliation":[{"name":"Perinatology Committee Japan Society of Obstetrics and Gynecology  Tokyo"},{"name":"Department of Obstetrics and Gynecology Nagasaki University Faculty of Medicine  Nagasaki"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,25]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Japan Association of Obstetricians and Gynecologists.Japanese Maternal Death Registration investigated by Japan Association of Obstetricians and Gynecologists 2010\u20132012. 2013. (Cited 15 March 2015.) Available from URL:http:\/\/www.jaog.or.jp\/all\/document\/67_130710.pdf(in Japanese)."},{"key":"e_1_2_7_3_1","unstructured":"Japan Society of Obstetrics and Gynecology Japan Association of Obstetricians and Gynecologists Japan Society of Perinatal and Neonatal Medicine Japanese Society of Anesthesiologists The Japan Society of Transfusion Medicine and Cell Therapy.Clinical Guideline for Critical Bleeding in Obstetrics.2010. (Cited 15 March 2015.) Available from:www.jspnm.com\/topics\/data\/topics100414.pdf(in Japanese)."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181c039e6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000288515.48066.99"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2009.08.018"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2011.02921.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e3181cc4378"},{"key":"e_1_2_7_9_1","unstructured":"Agence nationale de s\u00e9curit\u00e9 du m\u00e9dicament et des produits de sant\u00e9.RBU\u2010Novoseven: Syndrome h\u00e9morragique en obst\u00e9trique.2009. (Cited 15 March 2015.) Available from URL:http:\/\/ansm.sante.fr\/var\/ansm_site\/storage\/original\/application\/c57ea43f836f1869ce9de0a25df04428.pdf(in French)."},{"key":"e_1_2_7_10_1","unstructured":"Royal College of Obstetricians and Gynaecologists.Prevention and Management of Postpartum Haemorrhage. Green\u2010top Guideline. No. 52 2009. (Cited 15 March 2015.) 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