{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:24:37Z","timestamp":1785237877470,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T00:00:00Z","timestamp":1432512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"JSPS KAKENHI Grant-in-Aid for Scientific Research","award":["25462617"],"award-info":[{"award-number":["25462617"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the efficacy and safety of Kampo therapy based on Goreisan for lower abdominal lymphedema after surgical treatment of endometrial cancer or cervical cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Radical surgery, including retroperitoneal lymphadenectomy, was performed for endometrial cancer and cervical cancer. After surgery, Kampo therapy based on Goreisan and integrated physical therapy were provided for patients with lower abdominal lymphedema, especially lymphedema affecting the pubic\u2010inguinal\u2010vulval region. Goreisan (7.5g\/day) was given orally three times a day (tds). If a significant response was not observed, Saireito (9 g\/day; 3 g tds) or Gosyajinkigan (7.5 g\/day; 2.5 g tds) was administered concomitantly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 21 patients received treatment. The response rate to Goreisan monotherapy was 78%, with 22% being non\u2010responders. Median reduction of abdominal circumference was 2.1cm (95% CI 1.3\u20102.85). When Goreisan was combined with another Kampo agent, the response rate was 92% and the non\u2010response rate was 8%. The median reduction of the abdominal circumference was 2.85 cm (95% CI: 2.25\u20103.3). In particular, concomitant Goreisan and Saireito therapy achieved satisfactory results. No severe adverse reactions occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Goreisan\u2010based Kampo therapy might be effective and safe for lower abdominal lymphedema after retroperitoneal lymphadenectomy. We will perform a prospective control study in the near future.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12721","type":"journal-article","created":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T23:57:41Z","timestamp":1432598261000},"page":"1449-1456","source":"Crossref","is-referenced-by-count":17,"title":["Feasibility study on the effectiveness of Goreisan\u2010based Kampo therapy for lower abdominal lymphedema after retroperitoneal lymphadenectomy via extraperitoneal approach"],"prefix":"10.1111","volume":"41","author":[{"given":"Shinichi","family":"Komiyama","sequence":"first","affiliation":[{"name":"Department of Gynecology Toho University Ohashi Medical Center Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiaki","family":"Takeya","sequence":"additional","affiliation":[{"name":"Department of Gynecology Toho University Ohashi Medical Center Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rena","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Gynecology Toho University Ohashi Medical Center Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Gynecology Toho University Ohashi Medical Center Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaneyuki","family":"Kubushiro","sequence":"additional","affiliation":[{"name":"Department of Gynecology Toho University Ohashi Medical Center Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,25]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"CD007585","article-title":"Lymphadenectomy for the management of endometrial cancer","volume":"1","author":"May K","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_3_1","first-page":"131","article-title":"The verification of regulatory effects of Kampo formulation on body fluid using model mouse","volume":"17","author":"Ohnishi N","year":"2000","journal-title":"J Trad Med"},{"key":"e_1_2_8_4_1","first-page":"32","article-title":"The effect of Gorei\u2010san on the water distribution in the body (long term administration of Gorei\u2010san compared with short term administration)","volume":"16","author":"Orita M","year":"1998","journal-title":"J Trad Med"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/241629"},{"key":"e_1_2_8_6_1","first-page":"284","article-title":"The efficacy of goshajinkigan against lymphedema","volume":"25","author":"Abe Y","year":"2002","journal-title":"Kampo Igaku (Kampo Medicine)"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2013.0118"},{"key":"e_1_2_8_8_1","first-page":"77","article-title":"Evaluation of recurrence factors and Gorei\u2010san administration for chronic subdural hematoma after percutaneous subdural tapping","volume":"62","author":"Okamura A","year":"2013","journal-title":"Hiroshima J Med Sci"},{"key":"e_1_2_8_9_1","first-page":"91","article-title":"Preliminary evaluation of a new, more simplified physiotherapy technique for lymphatic drainage","volume":"35","author":"De Godoy JMP","year":"2002","journal-title":"Lymphology"},{"key":"e_1_2_8_10_1","first-page":"217","volume-title":"Lymphoedema","author":"Bellhouse S.","year":"2000"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/neh022"},{"key":"e_1_2_8_12_1","unstructured":"Common Terminology Criteria for Adverse Events (CTCAE)version 4.0. c2014[cited 30 Oct 2014]. 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