{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:37:24Z","timestamp":1767857844825,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T00:00:00Z","timestamp":1435276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"JSPS KAKENHI","award":["23592394, 22890045 and 25861476"],"award-info":[{"award-number":["23592394, 22890045 and 25861476"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Lysophosphatidic acid (LPA) is a member of a new class of lipid mediators and exerts varied physiological and pathological functions. The secreted protein, autotaxin (ATX), is a key enzymatic determinant of local LPA production. The primary aim of this study was to investigate the potential involvement of the placental ATX\u2013LPA system in pre\u2010eclampsia (PE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>We compared human placental ATX mRNA expression in pregnancies complicated by severe PE with that in healthy placentas using real\u2010time polymerase chain reaction. We further assessed whether these expression levels were associated with disease\u2010onset patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Placental transcription of ATX increased progressively during normal pregnancy. In the analysis for pre\u2010eclamptic placentas, the placental ATX expression in the early\u2010onset group, but not in late\u2010onset group, was significantly lower compared to normal controls. Multiple regression analysis revealed that occurrence of early\u2010onset PE, but not late\u2010onset PE, was a variable that was significantly associated with the placental ATX expression level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings support our previous work showing reduced ATX antigen levels in the peripheral blood of pre\u2010eclamptic women. A disturbance in placental ATX production may be linked to poor placental development and systemic maternal symptoms in early\u2010onset PE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12742","type":"journal-article","created":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T06:19:27Z","timestamp":1435299567000},"page":"1406-1411","source":"Crossref","is-referenced-by-count":19,"title":["Placental autotaxin expression is diminished in women with pre\u2010eclampsia"],"prefix":"10.1111","volume":"41","author":[{"given":"Mayuko","family":"Ichikawa","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Nagamatsu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danny 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