{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T14:38:27Z","timestamp":1786804707890,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T00:00:00Z","timestamp":1437436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Chemotherapy\u2010induced nausea and vomiting (CINV) can affect a patient's quality of life, leading to poor compliance with further treatments. Previous studies have provided minimal data about carboplatin\u2010based regimens. Female sex is a known risk factor for CINV. The purpose of this study was to evaluate palonosetron plus single\u2010dose dexamethasone (DEX) for preventing CINV caused by carboplatin plus paclitaxel combination therapy (TC regimen) in patients with gynecologic cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Patients were recruited for this phase\u2010II, multicenter, randomized trial from 12 hospitals in Hokkaido, Japan. Eligible patients were women with uterine cervical, endometrial or ovarian cancer scheduled to receive conventional TC regimen or dose\u2010dense TC regimen; 116 patients were randomly assigned to receive palonosetron in combination with 1\u2010day DEX or 3\u2010day DEX.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the overall period, complete response (CR) was observed in 67.9% (95% confidence interval, 53.7\u201380.1) of patients in the 3\u2010day DEX arm, and 60.7% (95% confidence interval, 46.8\u201373.5) of patients in the 1\u2010day DEX arm; CR was significantly lower in the 1\u2010day DEX arm if motion sickness was already present (<jats:italic>P<\/jats:italic>\u2009=\u20090.0370). In the severe hyperemesis gravidarum cohort, CR in the 1\u2010day DEX arm tended to be lower than in the 3\u2010day DEX arm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Combination therapy of palonosetron and 1\u2010day DEX was effective for subjects undergoing a TC regimen for gynecologic cancers. However, the possibility of reduced efficacy of 1\u2010day only DEX therapy in women undergoing a TC regimen could not be refuted and requires further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12748","type":"journal-article","created":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T02:44:13Z","timestamp":1437533053000},"page":"1607-1613","source":"Crossref","is-referenced-by-count":15,"title":["Palonosetron in combination with 1\u2010day versus 3\u2010day dexamethasone for prevention of nausea and vomiting following paclitaxel and carboplatin in patients with gynecologic cancers: A randomized, multicenter, phase\u2010II trial"],"prefix":"10.1111","volume":"41","author":[{"given":"Motoki","family":"Matsuura","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics Sapporo Medical University  Sapporo Japan"},{"name":"Department of Gynecology and Obstetrics Nikko Memorial Hospital  Muroran Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiro","family":"Satohisa","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Sapporo Medical University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizue","family":"Teramoto","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Sapporo Medical University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoichi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Sapporo Medical University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Sapporo Medical University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics NTT Sapporo Hospital  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Mizunuma","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Kitami Red Cross Hospital  Kitami Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Hakodate Goryokaku Hospital  Hakodate Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Esashi Hospital  Esashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Sapporo Medical University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1988.6.11.1746"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00434947"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyg083"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.4-3-191"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.34.4614"},{"key":"e_1_2_6_7_1","unstructured":"MASCC\/ESMO Antiemetic Guidelines. 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