{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:55:19Z","timestamp":1780631719540,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Pre\u2010eclampsia is a hypertensive disease that is characterized by high blood pressure and proteinuria after 20 gestational weeks and complicates 3\u20138% of all pregnancies. It is classified as either mild or severe pre\u2010eclampsia according to severity, and the aim of this study was to investigate the structural differences between these two classifications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Placenta samples were collected from 68 women who underwent cesarean delivery. Total volume of villi and numerical density of vascular endothelial growth factor (VEGF)\u2010 and placental growth factor (PIGF)\u2010positive cells were estimated on stereology and evaluated using one\u2010way ANOVA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significantly difference in total villi volumes between the groups (<jats:italic>P<\/jats:italic> &gt; 0.05). In contrast, on immunohistochemistry, the numerical density of VEGF\u2010positive cells in severe pre\u2010eclampsia was significantly different to the control and mild pre\u2010eclampsia groups (<jats:italic>P<\/jats:italic>&lt;0.05). Additionally, the numerical density of PIGF\u2010positive cells in the mild and severe pre\u2010eclampsia group was significantly higher than in the control group (<jats:italic>P<\/jats:italic>&lt;0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is no relationship between villi volume and pre\u2010eclampsia, although growth factors play a role in placental changes. The present results were supported by histopathology and several studies in the literature.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12751","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T16:16:43Z","timestamp":1436890603000},"page":"1533-1540","source":"Crossref","is-referenced-by-count":15,"title":["Role of vascular endothelial growth factor and placental growth factor expression on placenta structure in pre\u2010eclamptic pregnancy"],"prefix":"10.1111","volume":"41","author":[{"given":"Emel","family":"Kurtoglu","sequence":"first","affiliation":[{"name":"Departments of Obstetrics and Gynecology  Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berrin Z.","family":"Altunkaynak","sequence":"additional","affiliation":[{"name":"Histology and Embryology Ondokuz Mayis University  Samsun 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