{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T03:23:21Z","timestamp":1776914601795,"version":"3.51.2"},"reference-count":7,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,6,21]],"date-time":"2015-06-21T00:00:00Z","timestamp":1434844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"JSPS KAKENHI","award":["25861488"],"award-info":[{"award-number":["25861488"]}]},{"name":"MEXT KAKENHI \u2018Constructive Developmental Science\u2019","award":["24119004"],"award-info":[{"award-number":["24119004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Soluble fms\u2010like tyrosine kinase\u20101 (sFlt1), a circulating vascular endothelial growth factor receptor 1 antagonist, is associated with the pathogenesis of pre\u2010eclampsia. Extracorporeal removal of sFlt1 (sFlt1 apheresis) is emerging as a treatment for pre\u2010eclampsia. We performed sFlt1 apheresis for a patient with very early onset pre\u2010eclampsia, beginning at 15 weeks\u2019 gestation. She underwent sFlt1 apheresis 13 times from 19 to 23 weeks\u2019 gestation. The series of treatments lowered circulating sFlt1, stabilized blood pressure, reduced urinary protein, and preserved renal function, which contributed to a successful prolongation of pregnancy for 4 weeks and a live birth at 23<jats:sup>+3<\/jats:sup> weeks\u2019 gestation. Further studies are necessary for clinical application of sFlt1 apheresis as sFlt1 might have a protective function for the placenta and fetus in pre\u2010eclampsia.<\/jats:p>","DOI":"10.1111\/jog.12760","type":"journal-article","created":{"date-parts":[[2015,6,22]],"date-time":"2015-06-22T01:10:49Z","timestamp":1434935449000},"page":"1661-1663","source":"Crossref","is-referenced-by-count":20,"title":["Case of soluble fms\u2010like tyrosine kinase 1 apheresis in severe pre\u2010eclampsia developed at 15 weeks\u2019 gestation"],"prefix":"10.1111","volume":"41","author":[{"given":"Baku","family":"Nakakita","sequence":"first","affiliation":[{"name":"Department Gynecology and Obstetrics Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruta","family":"Mogami","sequence":"additional","affiliation":[{"name":"Department Gynecology and Obstetrics Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Kondoh","sequence":"additional","affiliation":[{"name":"Department Gynecology and Obstetrics Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Department of Nephrology Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoko","family":"Yanagita","sequence":"additional","affiliation":[{"name":"Department of Nephrology Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuo","family":"Konishi","sequence":"additional","affiliation":[{"name":"Department Gynecology and Obstetrics Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17987-2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17189"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.034793"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000268512.26170.ad"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2003.02134.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-0968.2003.00066.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI76864"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12760","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12760","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.12760","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T20:37:24Z","timestamp":1696192644000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.12760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,21]]},"references-count":7,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/jog.12760"],"URL":"https:\/\/doi.org\/10.1111\/jog.12760","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,21]]}}}