{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T11:00:23Z","timestamp":1789210823574,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,9,30]],"date-time":"2015-09-30T00:00:00Z","timestamp":1443571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373843"],"award-info":[{"award-number":["81373843"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to evaluate the preventive effect of the ligustrazine nanoparticles nano spray (LNNS) for postoperative peritoneal adhesions in female rat models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Fifty Wistar female rats weighting 250\u2013300\u2009g were randomly assigned to seven equal groups. All animals in the seven groups underwent midline laparotomy and ceca were abraded with sterile rasp. Group 1 underwent sham operations without treatment. In group 2, a postoperative peritoneal adhesion model was created, but no medication was given. In group 3, a postoperative peritoneal adhesion model was treated with LNNS, 2.5\u2009mg\/kg. In group 4, a postoperative peritoneal adhesion model was treated with LNNS, 5\u2009mg\/kg. In group 5, a postoperative peritoneal adhesion model was treated with LNNS, 10\u2009mg\/kg. In group 6, a postoperative peritoneal adhesion model was treated with polylactic acid (PLA) nanoparticle. In group 7, a postoperative peritoneal adhesion model was treated with ligustrazine, 2.5\u2009mg\/kg. Ten days after surgery, macroscopic and pathologic assessments were performed, and peritoneal fluid samples were collected in each group. The levels of tumor necrosis factor\u2010\u03b1, tissue plasminogen activator and plasminogen activator inhibitor\u20101 in peritoneal fluid were determined by enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The adhesion score and extent of groups 4 and 5 was lower than that of group 2 in macroscopic assessment (<jats:italic>P<\/jats:italic> &lt; 0.05). A comparison of tumor necrosis factor\u2010\u03b1 and tissue plasminogen activator level in the peritoneal fluid also demonstrated significant differences among groups 2, 4 and 5 (<jats:italic>P<\/jats:italic> &lt; 0.05). The levels of plasminogen activator inhibitor\u20101 in peritoneal fluid in the LNNS groups were decreased compared to group 1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We suggest that LNNS could reduce peritoneal adhesion formation and it could be applied as a novel intervention for postoperative peritoneal adhesion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12807","type":"journal-article","created":{"date-parts":[[2015,9,30]],"date-time":"2015-09-30T08:07:56Z","timestamp":1443600476000},"page":"1942-1950","source":"Crossref","is-referenced-by-count":17,"title":["Effect of intra\u2010abdominal administration of ligustrazine nanoparticles nano spray on postoperative peritoneal adhesion in rat model"],"prefix":"10.1111","volume":"41","author":[{"given":"Shuai","family":"Yan","sequence":"first","affiliation":[{"name":"Suzhou Hospital of Traditional Chinese Medicine  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin\u2010zi","family":"Yue","sequence":"additional","affiliation":[{"name":"Suzhou Hospital of Traditional Chinese Medicine  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zeng","sequence":"additional","affiliation":[{"name":"Library of Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Yue","sequence":"additional","affiliation":[{"name":"Yancheng Hospital of Traditional Chinese Medicine  Yancheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010lin","family":"Li","sequence":"additional","affiliation":[{"name":"Library of Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010qin","family":"Mao","sequence":"additional","affiliation":[{"name":"School of Pharmacy Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Yang","sequence":"additional","affiliation":[{"name":"Library of Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62002-4"},{"key":"e_1_2_7_3_1","first-page":"769","article-title":"Intra\u2010abdominal adhesions: Definition, origin, significance in surgical practice, and treatment options","volume":"107","author":"Br\u00fcggmann D","year":"2010","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4272"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.8.380"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2010.09.034"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12172"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X13500559"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules17055412"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2009.04.005"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2013.10.074"},{"key":"e_1_2_7_12_1","first-page":"531","article-title":"Effect of ligustrazine hydrochloride on coagulation reaction and inflammation reaction in single valve replacement patients with rheumatic heart disease undergoing cardiopulmonary bypass","volume":"34","author":"Chen YJ","year":"2014","journal-title":"Chin J Integr Med"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2011.12.026"},{"key":"e_1_2_7_14_1","first-page":"1212","article-title":"Danhong injection, ligustrazine injection, combined absorbable biomembranes prevented adhesion of tendons after the repair operation: A clinical research","volume":"33","author":"Zhao ZW","year":"2013","journal-title":"Chin J Integr Med"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp900274u"},{"key":"e_1_2_7_16_1","first-page":"261","article-title":"Preparation technology and quality assay of ligustrazine poly lactic acid nanoparticles","volume":"35","author":"Zeng L","year":"2013","journal-title":"Chin Tradit Patent Med"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.1920080406"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2008.08.004"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-011-2041-4"},{"key":"e_1_2_7_20_1","first-page":"181","article-title":"Influence of abdominal incision on the formation of postoperative peritoneal adhesions: An experimental study in rats","volume":"162","author":"Moreno A","year":"1996","journal-title":"Eur J Surg"},{"key":"e_1_2_7_21_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1177\/000313480006600109","article-title":"Fibrin glue reduces intra\u2010abdominal adhesions to synthetic mesh in a rat ventral hernia model","volume":"66","author":"Toosie K","year":"2000","journal-title":"Am Surg"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800600204"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(99)70288-6"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2001.115102"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2002.02228.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/7.6.547"},{"key":"e_1_2_7_27_1","first-page":"230","article-title":"Present possibilities of prevention of adhesions and their immunologic aspects","volume":"64","author":"Crha I","year":"1999","journal-title":"Ceska Gynekol"},{"key":"e_1_2_7_28_1","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s00535-002-1103-6","article-title":"Effects of octreotide on epidermal growth factor receptor, tissue plasminogen activator, and plasminogen activator inhibitor during intraperitoneal adhesion formation","volume":"38","author":"Lai HS","year":"2003","journal-title":"J Gastroenterol"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000128208"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91125-T"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)58700-7"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3109\/19396368.2012.713439"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2014.07.056"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1082391"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lab.2003.09.005"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1067\/msy.1998.86984"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1382877"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12807","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12807","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.12807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T01:28:17Z","timestamp":1696210097000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.12807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,30]]},"references-count":36,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/jog.12807"],"URL":"https:\/\/doi.org\/10.1111\/jog.12807","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,30]]}}}