{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T19:12:45Z","timestamp":1784661165973,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T00:00:00Z","timestamp":1447113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Recent studies have demonstrated that the neural precursor cell expressed, developmentally downregulated 4\u2010like (Nedd4L) gene plays a role in the progression of various cancers. However, reports describing Nedd4L expression in ovarian cancer tissues are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A cohort (<jats:italic>n<\/jats:italic>\u2009=\u2009117) of archival formalin\u2010fixed, paraffin embedded resected normal ovarian epithelial tissues (<jats:italic>n<\/jats:italic>\u2009=\u200910), benign ovarian epithelial tumor tissues (<jats:italic>n<\/jats:italic>\u2009=\u200910), serous borderline ovarian epithelial tumor tissues (<jats:italic>n<\/jats:italic>\u2009=\u200914), mucous borderline ovarian epithelial tumor tissues (<jats:italic>n<\/jats:italic>\u2009=\u200911), and invasive ovarian epithelial cancer tissues (<jats:italic>n<\/jats:italic>\u2009=\u200972) were assessed for Nedd4L protein expression using immunohistochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nedd4L protein expression was significantly decreased in invasive ovarian epithelial cancer tissues compared to non\u2010cancer tissues (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Decreased Nedd4L protein expression correlated with clinical stage, pathological grade, lymph node metastasis and survival (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Nedd4L protein expression may be an independent prognostic marker of ovarian cancer development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12808","type":"journal-article","created":{"date-parts":[[2015,11,11]],"date-time":"2015-11-11T00:22:58Z","timestamp":1447201378000},"page":"1959-1964","source":"Crossref","is-referenced-by-count":19,"title":["Nedd4L expression is decreased in ovarian epithelial cancer tissues compared to ovarian non\u2010cancer tissue"],"prefix":"10.1111","volume":"41","author":[{"given":"Qiuyun","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Gynaecology and Obstetrics The Second Hospital of Jilin University  Changchun Jilin Province China"},{"name":"Department of Gynaecology and Obstetrics The Hospital of Binzhou Medical University Campus  Yantai Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghe","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Hospital of Binzhou Medical University Campus  Yantai Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manhua","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics The Second Hospital of Jilin University  Changchun Jilin Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Gi","sequence":"additional","affiliation":[{"name":"Department of Inspection Harbin Medical University Daqing Campus  Daqing Heilongjiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics The Hospital of Binzhou Medical University Campus  Yantai Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaole","family":"Han","sequence":"additional","affiliation":[{"name":"Department of College of Bioinformatics Science and Technology Harbin Medical University  Harbin Heilongjiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,10]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1012","article-title":"Benign, proliferative noninvasive (borderline), and invasive epithelial tumors of the ovary","volume":"35","author":"Seidman J","year":"2008","journal-title":"Glob Libr Women's 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