{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:14:20Z","timestamp":1792167260792,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,9,14]],"date-time":"2015-09-14T00:00:00Z","timestamp":1442188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004689","name":"CONDES","doi-asserted-by":"crossref","award":["0875-06"],"award-info":[{"award-number":["0875-06"]}],"id":[{"id":"10.13039\/501100004689","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The objective of this study was to determine the ability of biochemical analytes to identify adverse outcomes in pregnancies with Turner syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Maternal serum and amniotic fluid (AF) marker concentrations were measured in 73 singleton pregnancies with Turner syndrome (10\u201022 weeks of gestation). Fetal Turner syndrome was definitively established by cytogenetic analysis. Two subgroups, fetuses with hydrops fetalis versus fetuses with cystic hygroma, were compared. Receiver operating characteristic curves and relative risk were established for a cut\u2010off multiples of the median \u22653.5 for \u03b2\u2010subunit of human chorionic gonadotropin (hCG) or AF alpha\u2010fetoprotein (AFP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010nine (67%) of 73 pregnant women had an abnormal maternal serum. While levels of pregnancy\u2010associated plasma protein\u2010A and free \u03b2\u2010subunit (f\u03b2)\u2010hCG were not different to those of the control group, AFP, unconjugated estriol and \u03b2\u2010hCG concentrations were significantly different in the study group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), when compared to those of unaffected pregnancies. Levels of \u03b2\u2010hCG in pregnancies with hydrops fetalis were significantly higher than in those with cystic hygroma (<jats:italic>P<\/jats:italic> &lt;0.0001), as were AF\u2010AFP concentrations (<jats:italic>P<\/jats:italic> &lt;0.0015). In addition, abnormalities in both maternal serum \u03b2\u2010hCG and AF\u2010AFP predicted fetal death. The relative risk of adverse obstetric outcome was 10.667 (<jats:italic>P<\/jats:italic>\u2009=\u20090.0004; 95% confidence interval [CI]: 1.554\u201373.203) for \u03b2\u2010hCG and 2.19 (<jats:italic>P<\/jats:italic>\u2009=\u20090.0256; 95% CI: 1.001 to 4.779), for AF\u2010AFP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maternal serum \u03b2\u2010hCG and AF\u2010AFP levels may preferentially identify those Turner syndrome pregnancies with the highest risk of fetal death.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12813","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T03:40:03Z","timestamp":1442288403000},"page":"1891-1898","source":"Crossref","is-referenced-by-count":5,"title":["Elevated second\u2010trimester maternal serum \u03b2\u2010human chorionic gonadotropin and amniotic fluid alpha\u2010fetoprotein as indicators of adverse obstetric outcomes in fetal Turner syndrome"],"prefix":"10.1111","volume":"41","author":[{"given":"Francisco","family":"Alvarez\u2010Nava","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones Gen\u00e9ticas Universidad del Zulia  Maracaibo Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisol","family":"Soto","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Gen\u00e9ticas Universidad del Zulia  Maracaibo Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Lanes","sequence":"additional","affiliation":[{"name":"Unidad de Endocrinolog\u00eda Pedi\u00e1trica Hospital de Cl\u00ednicas Caracas  Caracas Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector","family":"Pons","sequence":"additional","affiliation":[{"name":"Centro de Medicina Experimental Universidad del Zulia  Maracaibo Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisandra","family":"Morales\u2010Machin","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Gen\u00e9ticas Universidad del Zulia  Maracaibo Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Bracho","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Gen\u00e9ticas Universidad del Zulia  Maracaibo Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05487-3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2003.95"},{"key":"e_1_2_7_4_1","first-page":"2","article-title":"Effect of the parental origin of the X\u2010chromosome on the clinical features, associated complications, the two\u2010year\u2010response to growth hormone (rhGH) and the biochemical profile in patients with Turner syndrome","volume":"10","author":"\u00c1lvarez\u2010Nava F","year":"2013","journal-title":"Int J Pediat Endocrinol"},{"key":"e_1_2_7_5_1","first-page":"712","article-title":"Ovarian function and in vitro fertilization (IVF) in Turner syndrome","volume":"9","author":"Hovatta O","year":"2012","journal-title":"Pediat Endocrinol Rev"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000095547"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-014-1420-x"},{"key":"e_1_2_7_8_1","first-page":"261","volume-title":"Human Embryonic and Fetal Death","author":"Warburton ID","year":"1981"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2006.25.6.711"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(200005)20:5<390::AID-PD824>3.0.CO;2-B"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200701000-00054"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(12)80031-7"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)70229-2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199609)16:9<853::AID-PD945>3.0.CO;2-9"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1093\/clinchem\/45.12.2259","article-title":"Turner syndrome and multiple\u2010marker screening","volume":"45","author":"Ruiz C","year":"1999","journal-title":"Clin Chem"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199905)19:5<476::AID-PD548>3.0.CO;2-B"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0223(200008)20:8<635::AID-PD868>3.0.CO;2-U"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050410001668257"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.06.099"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70334-0"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0223(200008)20:8<652::AID-PD882>3.0.CO;2-6"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.125240"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2008.07.017"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(96)02590-0"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118277"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpme.1973.1.2.104"},{"key":"e_1_2_7_27_1","first-page":"4","article-title":"Morphological characteristics of monosomy X in spontaneous abortions","volume":"31","author":"Canki N","year":"1988","journal-title":"Ann Genet"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004175"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.151"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.230"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12813","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12813","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.12813","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T01:28:56Z","timestamp":1696210136000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.12813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,14]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/jog.12813"],"URL":"https:\/\/doi.org\/10.1111\/jog.12813","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,14]]}}}