{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:03:07Z","timestamp":1789974187912,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T00:00:00Z","timestamp":1447113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The objective of this study was to identify the relationship between fetal growth restriction (FGR) and oxidative stress. The mechanisms that protect against oxidative stress in the local microenvironment were investigated by comparing the activities of the markers, both in the circulation and myometrium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Myometrial tissue and serum levels of malondialdehyde (MDA), xanthine oxidase (XO), catalase (CAT) and superoxide dismutase (SOD) markers were measured in 20 FGR and 20 healthy pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean duration of gestation at delivery was shorter (<jats:italic>P<\/jats:italic> = 0003) and the mean birthweight was lower <jats:italic>P<\/jats:italic> &lt; 0001) in the FGR study group compared with the control group, as expected. While MDA and CAT concentrations were higher in the serum (<jats:italic>P<\/jats:italic> &lt; 0.02 and <jats:italic>P<\/jats:italic> &lt; 0.01, respectively), but lower in the myometrial samples (<jats:italic>P<\/jats:italic> &lt; 0.01) in the FGR versus the control group, XO and myometrial SOD values were comparable in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although our data demonstrated that FGR is associated with oxidative stress, the exact role and mechanism of the oxidant and antioxidant imbalance is obscure. We speculate that despite limited local synthesis of CAT, effective and efficient removal of MDA in the uterine environment explains high MDA and CAT serum concentrations in women with FGR. Alternatively, a well\u2010functioning myometrial system could rescue the fetus from reactive oxygen species, as demonstrated by lowered MDA and depleted CAT resulting from hyperconsumption. Elevated serum MDA and CAT levels in the serum may reflect the \u2018spillover\u2019 of these markers from the uterus to the circulation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12857","type":"journal-article","created":{"date-parts":[[2015,11,11]],"date-time":"2015-11-11T02:48:54Z","timestamp":1447210134000},"page":"29-35","source":"Crossref","is-referenced-by-count":20,"title":["Circulating and myometrial markers of oxidative stress in pregnant women with fetal growth restriction"],"prefix":"10.1111","volume":"42","author":[{"given":"Ebru","family":"Biberoglu","sequence":"first","affiliation":[{"name":"Department of Perinatology, Zekai Tahir Burak Women Health Care Education and Research Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kutay","family":"Biberoglu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Gazi University Medical School  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse","family":"Kirbas","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Zekai Tahir Burak Women Health Care Education and Research Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Korkut","family":"Daglar","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Zekai Tahir Burak Women Health Care Education and Research Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metin","family":"Genc","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Ankara University Medical Faculty  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aslihan","family":"Avci","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Ankara University Medical Faculty  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuri","family":"Danisman","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Zekai Tahir Burak Women Health Care Education and Research Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2008.04.010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2007.01.013"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dml016"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2010.06.001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2015.02.003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.02.017"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715760701291647"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.10.2306"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.04.024"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(62)90181-9"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-091302-2.50032-3"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/34.3.497"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19861015)58:8<1658::AID-CNCR2820580814>3.0.CO;2-7"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612054065747"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/plac.2002.0932"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.111935"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)62060-3"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-004-0677-x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61778-6"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1028-4559(09)60224-2"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4004(97)80064-1"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64733-5"},{"key":"e_1_2_7_25_1","first-page":"897","article-title":"Sera antioxidant activity in uncomplicated and preeclamptic pregnancies","volume":"79","author":"Davidge ST","year":"1992","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.115281"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874288201206010131"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)70374-5"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.04.035"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep.1.00437"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12857","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12857","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.12857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T20:55:55Z","timestamp":1696280155000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.12857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,10]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/jog.12857"],"URL":"https:\/\/doi.org\/10.1111\/jog.12857","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,10]]}}}