{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:48:07Z","timestamp":1791888487960,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T00:00:00Z","timestamp":1447113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to determine whether cervicovaginal interleukin (IL)\u20101\u03b2, IL\u20106 and IL\u20108 levels, and cervical length, alone or in combination, could predict impending preterm delivery in women with preterm labor and intact membranes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Cervicovaginal swab samples for IL\u20101\u03b2, IL\u20106, and IL\u20108 assays were taken from 136 consecutive women with preterm labor (23\u201334 weeks) before the transvaginal ultrasonography examination to measure cervical length. The primary outcome measurement was spontaneous preterm delivery within 7 days of sampling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Spontaneous preterm delivery within 7 days occurred in 28.6% (39\/136) of patients. Receiver\u2013operator characteristic (ROC) curves indicated that cervical length (<jats:italic>P<\/jats:italic> &lt; 0.001), cervicovaginal IL\u20106 (<jats:italic>P<\/jats:italic> &lt; 0.001) and IL\u20108 (<jats:italic>P<\/jats:italic> = 0.014), but not IL\u20101\u03b2, could predict delivery within 7 days. According to the logistic regression analysis, high cervicovaginal IL\u20108 (<jats:italic>P<\/jats:italic> = 0.008) and IL\u20106 (<jats:italic>P<\/jats:italic> = 0.038) levels and short cervical length (<jats:italic>P<\/jats:italic> &lt; 0.001) were significantly associated with delivery within 7 days, even after controlling for baseline variables. A combination of cervix length and cervicovaginal IL\u20108 increased the specificity of detecting delivery within 7 days to 92.8%, which was superior to either test alone (<jats:italic>P<\/jats:italic> &lt; 0.001), but the sensitivity was only 56.4%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In women with preterm labor, among the parameters assessed, cervicovaginal IL\u20106 and IL\u20108 and cervical length are the most important parameters in predicting impending preterm delivery. A combination of cervix length and cervicovaginal IL\u20108 appeared to be the best for predicting impending preterm delivery, but the relatively low sensitivity of this test may limit its clinical usefulness.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12882","type":"journal-article","created":{"date-parts":[[2015,11,11]],"date-time":"2015-11-11T03:08:10Z","timestamp":1447211290000},"page":"158-165","source":"Crossref","is-referenced-by-count":35,"title":["Prediction of impending preterm delivery based on sonographic cervical length and different cytokine levels in cervicovaginal fluid in preterm labor"],"prefix":"10.1111","volume":"42","author":[{"given":"Eun Young","family":"Jung","sequence":"first","affiliation":[{"name":"Departments of Obstetrics and Gynecology Seoul National University College of Medicine, Seoul National University, Bundang Hospital  Seongnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Inje University College of Medicine, Ilsan\u2010Paik Hospital  Gyeonggi South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aeli","family":"Ryu","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology Seoul National University College of Medicine, Seoul National University, Bundang Hospital  Seongnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Youn","family":"Lee","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology Seoul National University College of Medicine, Seoul National University, Bundang Hospital  Seongnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo\u2010hyun","family":"Cho","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology Seoul National University College of Medicine, Seoul National 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