{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:07:06Z","timestamp":1789614426839,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Seoul National University Bundang Hospital Research Fund","award":["11-2011-019"],"award-info":[{"award-number":["11-2011-019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Few studies have reported that human papillomavirus (HPV) tests using menstrual blood (MB) may be a convenient and effective screening modality for cervical cancer. Therefore, we aimed to investigate the efficacy of detecting high\u2010risk (HR)\u2010HPV from MB in women with high\u2010grade squamous intraepithelial lesions or HR\u2010HPV infections dependent on menstrual days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In this prospective exploratory pilot study, a clinical trial was conducted in 19 women. On enrollment into the study, gynecologists collected cervical cells. On the first and second day of menstruation, MB was self\u2010collected by patients using a sanitary pad with a filter. The distribution of HPVs from MB and the accuracy of menstrual HR\u2010HPV tests were evaluated using HPV genotyping. The agreement rate of detecting HR\u2010HPVs using cervical and MB samples was also investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sensitivity, specificity, positive and negative predictive values of the MB HR\u2010HPV test for detecting cervical intraepithelial neoplasia (CIN) 3 or worse were 87.5%, 45.5%, 53.8%, and 83.3%, respectively, during both menstrual cycle day (MCD) 1 and 2 and MCD 1 only; and 62.5%, 27.3%, 38.5%, and 50.0%, respectively, during MCD 2 only. For CIN 3 or worse, the agreement rate between positive cervical and MB HR\u2010HPV test results was 87.5% during MCD 1 and 62.5% during MCD 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We demonstrated the possibility of using the MB HPV test as a screening modality for cervical cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12888","type":"journal-article","created":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T10:58:39Z","timestamp":1449053919000},"page":"319-324","source":"Crossref","is-referenced-by-count":9,"title":["Detection of high\u2010risk human papillomavirus using menstrual blood in women with high\u2010grade squamous intraepithelial lesions or high\u2010risk human papillomavirus infections: A pilot study"],"prefix":"10.1111","volume":"42","author":[{"given":"Banghyun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University Bundang Hospital  Seongnam\u2010Si Gyeonggi\u2010Do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye\u2010Yon","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hallym University Dongtan Sacred Heart Hospital  Hwaseong\u2010Si Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kum Jin","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University Bundang Hospital  Seongnam\u2010Si Gyeonggi\u2010Do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kidong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University Bundang Hospital  Seongnam\u2010Si Gyeonggi\u2010Do Republic of Korea"},{"name":"Seoul National University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Ryeol","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University Bundang Hospital  Seongnam\u2010Si Gyeonggi\u2010Do Republic of Korea"},{"name":"Seoul National University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Joo","family":"Moon","sequence":"additional","affiliation":[{"name":"Goodgene Inc. Koyang\u2010Si  Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Hong","family":"No","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University Bundang Hospital  Seongnam\u2010Si Gyeonggi\u2010Do Republic of Korea"},{"name":"Seoul National University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Beom","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University Bundang Hospital  Seongnam\u2010Si Gyeonggi\u2010Do Republic of Korea"},{"name":"Seoul National University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"e_1_2_7_3_1","first-page":"1304","volume-title":"Berek & Novak's Gynecology","author":"Miller C","year":"2012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21139"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-11-257"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1258\/jms.2009.009073"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70570-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10255"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01996-09"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1258\/095646207780132532"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1158\/1055-9965.2153.13.12","article-title":"Distribution and prevalence of human papillomavirus genotypes in routine pap smear of 2,470 Korean women determined by DNA chip","volume":"13","author":"Hwang HS","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.06.095"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-200211000-00003"},{"key":"e_1_2_7_14_1","first-page":"81","article-title":"Assessment of HPV DNA test value in management women with cytological findings of ASC\u2010US, CIN1 and CIN2","volume":"34","author":"Pajtler M","year":"2010","journal-title":"Coll Antropol"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.14.1749"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir049"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20875"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12888","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12888","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.12888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T16:45:14Z","timestamp":1696265114000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.12888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,2]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/jog.12888"],"URL":"https:\/\/doi.org\/10.1111\/jog.12888","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,2]]}}}