{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:44:39Z","timestamp":1761489879623},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T00:00:00Z","timestamp":1450742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Vice Chancellor for Research, Kurdistan University of Medical Sciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Ectopic pregnancy is a medical emergency. The classic treatment for this condition is surgery but early diagnosis allows for non\u2010surgical treatment. In recent years, intramuscular methotrexate has been considered, due to easy administration, its less invasive nature and low complications, but there are arguments about its effects. The aim of this study was to evaluate tubal patency after treatment of ectopic pregnancy with methotrexate and related factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study was conducted on 80 women with ectopic pregnancy who were admitted to Sanandaj Be'sat Hospital in 2014. Patients who had successful treatment for ectopic pregnancy with single or multiple doses of methotrexate 50 mL\/m<jats:sup>2<\/jats:sup> were enrolled. Three to 6 months after treatment, the patients were evaluated for tubal patency by hysterosalpingography. Data were analyzed using <jats:sc>spss<\/jats:sc>, <jats:italic>t<\/jats:italic>\u2010tests, \u03c7<jats:sup>2<\/jats:sup>\u2010test and logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The tubal patency rate after treatment of ectopic pregnancy with methotrexate was 75% in hysterosalpingography. The average size of the ectopic pregnancy mass of women with open fallopian tubes was 22.5 \u00b1 7.0\u00a0mm and for women with closed fallopian tubes it was 34.7 \u00b1 10.0\u00a0mm (<jats:italic>P<\/jats:italic> = 0.0001). \u03b2\u2010human chorionic gonadotropin levels were 642.1\u00a0\u00b1\u00a0850.5 in women with open fallopian tubes and 3816.3\u00a0\u00b1\u00a04487.3 for women with closed fallopian tubes (<jats:italic>P<\/jats:italic> = 0.0001). There was no significant correlation statistically between tubal patency with a history of stillbirth and number of pregnancies (<jats:italic>P<\/jats:italic> &gt; 0.5). There was a statistically significant relation between tubal patency and the number of births and also methotrexate dose (<jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Treatment of ectopic pregnancy with methotrexate is effective for saving tubal patency. Levels of human chorionic gonadotrophin\u2010\u03b2\u00a0&lt;\u00a01745, the treatment regimen of methotrexate (single or multiple doses) and ectopic pregnancy mass size smaller than 33.5 mm are significant predictors of tubal patency.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12894","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T04:04:45Z","timestamp":1450843485000},"page":"286-290","source":"Crossref","is-referenced-by-count":4,"title":["Frequency and related factors of tubal patency after methotrexate treatment in women with ectopic pregnancy"],"prefix":"10.1111","volume":"42","author":[{"given":"Fariba","family":"Seyedoshohadaei","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, Faculty of Medicine Kurdistan University of Medical Sciences  Sanandaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robabeh","family":"Mohammadbeigi","sequence":"additional","affiliation":[{"name":"Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atefe","family":"Tahmuri","sequence":"additional","affiliation":[{"name":"Kurdistan University of Medical Sciences  Sanandaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebrahim","family":"Ghaderi","sequence":"additional","affiliation":[{"name":"Research Center for Social Determinants of Health Kurdistan University of Medical Sciences  Sanandaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,22]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"46","article-title":"Ectopic pregnancy\u2014United States, 1990\u20131992","volume":"44","author":"Centers for Disease Control and Prevention (CDC)","year":"1995","journal-title":"Morb Mortal Wkly 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