{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T04:55:53Z","timestamp":1764046553694},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,8]],"date-time":"2015-12-08T00:00:00Z","timestamp":1449532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Heat shock proteins (HSPs) are synthesized in virtually all organisms in response to increases in temperature. They are associated with a relaxant effect on the human myometrium and are present in decreased concentration in the myometrium at the time of labor. Paeoniflorin is derived from <jats:italic>Paeonia lactiflora<\/jats:italic> and has been shown to induce the synthesis of HSPs in cultured mammalian cells. The purpose of the study was to evaluate the effect of paeoniflorin on human uterine contractility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Samples of human myometrium were taken at lower segment cesarean section. Dissected muscle strips were suspended under isometric conditions and exposed to cumulative additions of paeoniflorin in concentrations ranging from 1 nmol\/L to 10 mol\/L. Control experiments were simultaneously performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Paeoniflorin was found to exert an inhibitory effect on spontaneous and agonist\u2010induced contractions compared to control strips. The mean maximal inhibition values were: 42.21% \u00b1 9.26 for spontaneous contractions (<jats:italic>n<\/jats:italic> = 6; <jats:italic>P<\/jats:italic> &lt; 0.0001) and 47.84% \u00b1 9.05 for oxytocin\u2010induced contractions (<jats:italic>n<\/jats:italic> = 6; <jats:italic>P<\/jats:italic> &lt; 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The HSP inducing compound, paeoniflorin, had a relaxant effect on human uterine contractility <jats:italic>in vitro<\/jats:italic>. These results reinforce the fact that HSPs may play a physiological role in the onset of labor and may also provide future targets for novel tocolytic treatments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12895","type":"journal-article","created":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T05:15:08Z","timestamp":1449638108000},"page":"302-306","source":"Crossref","is-referenced-by-count":6,"title":["Paeoniflorin, a novel heat\u2010shock protein inducing compound, and human myometrial contractility <i>in vitro<\/i>"],"prefix":"10.1111","volume":"42","author":[{"given":"Mark P.","family":"Hehir","sequence":"first","affiliation":[{"name":"NUI Galway, Obstetrics and Gynaecology Clinical Science Institute  Newcastle Galway Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.","family":"Morrison","sequence":"additional","affiliation":[{"name":"NUI Galway, Obstetrics and Gynaecology Clinical Science Institute  Newcastle Galway Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.103.2.321"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.115.14.2809"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1068408"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2756425"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2188360"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1379\/CSC-51R.1"},{"key":"e_1_2_6_8_1","volume-title":"Heat Shock from Bacteria to Man","author":"Schlesinger MJ","year":"1982"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)36606-1"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2008.04.005"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0593"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.278549"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069141"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-951678"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2007.07.013"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb1978.5.921"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-014-0835-y"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2011.01827.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.01.106"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0574"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.07.013"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.01.002"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0662"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.5812\/ijem.3644"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12895","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12895","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.12895","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T16:45:11Z","timestamp":1696265111000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.12895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,8]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/jog.12895"],"URL":"https:\/\/doi.org\/10.1111\/jog.12895","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,8]]}}}