{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T23:33:39Z","timestamp":1722987219554},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T00:00:00Z","timestamp":1449705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to compare vaginal misoprostol versus intravenous (i.v.) oxytocin in the management of pregnancies with second\u2010trimester intrauterine fetal death (IUFD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This randomized clinical trial was conducted on 85 pregnant women with IUFD and unripe cervix who were admitted for labor induction. Forty were randomly allocated to receive 200 mcg vaginal misoprostol every 12 h, and 45 were randomly assigned to receive high\u2010dose i.v. oxytocin (starting from 6 mU\/min to reach the maximum dose of 40 mU\/min). This study is registered at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.irct.ir\">www.irct.ir<\/jats:ext-link> (IRCT201307159568N5).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The induction\u2010to\u2010delivery interval in the misoprostol group (10.5 \u00b1 5.3 [range 4\u201327] h) was significantly lower than that in the oxytocin group (14 \u00b1 6.8 [range 4\u201330] h) (<jats:italic>P<\/jats:italic> = 0.009). The total hospital stay in the misoprostol group (22.6 \u00b1 9.5 [range 12\u201348] h) was significantly lower than that in the oxytocin group (35.3 \u00b1 16.4 [range 12\u201372] h) (<jats:italic>P<\/jats:italic> = 0.000). Although the successful induction rate was higher in the misoprostol group, this was not significant (95% <jats:italic>vs<\/jats:italic> 86.7%, <jats:italic>P<\/jats:italic> = 0.1). Placenta retention occurred more in the oxytocin group (20% <jats:italic>vs<\/jats:italic> 5%, <jats:italic>P<\/jats:italic> = 0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both vaginal misoprostol and high\u2010dose i.v. oxytocin are highly effective in labor induction in second\u2010trimester pregnancies with IUFD and an unripe cervix. However, vaginal misoprostol seems to be superior to i.v. oxytocin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12910","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T11:17:01Z","timestamp":1449746221000},"page":"246-251","source":"Crossref","is-referenced-by-count":9,"title":["Vaginal misoprostol versus intravenous oxytocin for the management of second\u2010trimester pregnancies with intrauterine fetal death: A randomized clinical trial"],"prefix":"10.1111","volume":"42","author":[{"given":"Zhila","family":"Abediasl","sequence":"first","affiliation":[{"name":"Maternal, Fetal and Neonatal Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"Shariati Hospital Hormozgan University of Medical Sciences  Bandar\u2010Abbas Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahdi","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Maternal, Fetal and Neonatal Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parichehr","family":"Pooransari","sequence":"additional","affiliation":[{"name":"Shohadaye Tajrish Hospital Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Farahani","sequence":"additional","affiliation":[{"name":"Maternal, Fetal and Neonatal Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farah","family":"Kalani","sequence":"additional","affiliation":[{"name":"Shariati Hospital Hormozgan University of Medical Sciences  Bandar\u2010Abbas 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