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The study was a prospective cohort study in a tertiary infertility center in <jats:styled-content style=\"fixed-case\">Abu Dhabi<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">United Arab Emirates<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">UAE<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The subjects consisted of 100 PCOS CC\u2010resistant patients who attended between <jats:styled-content style=\"fixed-case\">January<\/jats:styled-content> 2014 and <jats:styled-content style=\"fixed-case\">January<\/jats:styled-content> 2015. Fifty received CC again but in accordance with the stair\u2010step protocol, and the other 50 received the standard gonadotrophin treatment used in the center in which the study was conducted. The primary outcome measure was dominant follicle achievement; the secondary outcome measures were (i) clinical pregnancy rate; (ii) time to ovulation measured from treatment initiation to sonographic confirmation of a dominant follicle in days; and (iii) adverse effect occurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no difference between the two treatment modalities concerning the ability to achieve a dominant follicle or the clinical pregnancy rate. The time to ovulation was significantly shorter with the CC stair\u2010step protocol than with gonadotrophin treatment. Ovarian hyperstimulation syndrome and ovarian cyst formation were more likely to occur with gonadotrophin treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Clomiphene citrate stair\u2010step protocol can be offered to PCOS CC\u2010resistant patients as an alternative to gonadotrophin therapy with similar efficacy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12940","type":"journal-article","created":{"date-parts":[[2016,1,20]],"date-time":"2016-01-20T03:02:49Z","timestamp":1453258969000},"page":"547-553","source":"Crossref","is-referenced-by-count":8,"title":["Is clomiphene citrate stair\u2010step protocol a good alternative to gonadotrophins in clomiphene\u2010resistant PCO patients? 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