{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:29:19Z","timestamp":1791271759885,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T00:00:00Z","timestamp":1454371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate whether serum levels of neopterin and inflammatory markers including C\u2010reactive protein (CRP), tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), interleukin\u20106 (IL\u20106) and oxidative status indicators were altered in patients with hyperemesis gravidarum (HG) compared to asymptomatic pregnant women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study was performed including 30 pregnant women with HG (mean age: 30.67 \u00b1 6.68) and 30 asymptomatic pregnant women (mean age: 28.00 \u00b1 5.30). Demographic features, obstetric history, and the Pregnancy Unique Quantification of Emesis\/Nausea (PUQE) index were noted. Complete blood count, serum biochemical assay and measurement of CRP, TNF\u2010\u03b1, IL\u20106, total antioxidant status and total oxidative status (TOS) levels were taken and compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>White blood cell count (<jats:italic>P<\/jats:italic> = 0.013), platelet count (<jats:italic>P<\/jats:italic> = 0.015), TOS (<jats:italic>P<\/jats:italic> &lt; 0.001), and PUQE score (<jats:italic>P<\/jats:italic> &lt; 0.001) were remarkably higher in HG pregnancies. On the other hand, serum levels of lactate dehydrogenase, (<jats:italic>P<\/jats:italic> &lt; 0.001), sodium (<jats:italic>P<\/jats:italic> &lt; 0.001), potassium (<jats:italic>P<\/jats:italic> &lt; 0.001), chloride (<jats:italic>P<\/jats:italic> &lt; 0.001) and TAS (<jats:italic>P<\/jats:italic> &lt; 0.001) were higher in the control group. There was no difference in the levels of neopterin, CRP, TNF\u2010\u03b1 and IL\u20106. In patients with HG, a positive correlation was detected between TOS and serum levels of lactate dehydrogenase, while TNF\u2010\u03b1, IL\u20106 and neopterin were positively correlated with hemoglobin levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results demonstrated no association between inflammation and HG. Elucidation of the pathophysiology and complex interaction between various inflammatory processes in HG necessitates further trials on larger series.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12949","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T07:09:40Z","timestamp":1454396980000},"page":"618-624","source":"Crossref","is-referenced-by-count":15,"title":["Serum levels of neopterin, inflammatory markers and oxidative stress indicators in hyperemesis gravidarum"],"prefix":"10.1111","volume":"42","author":[{"given":"Senem Yaman","family":"Tunc","sequence":"first","affiliation":[{"name":"School of Medicine, Departments of Obstetrics and Gynecology Dicle University  Diyarbakir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Agacayak","sequence":"additional","affiliation":[{"name":"School of Medicine, Departments of Obstetrics and Gynecology Dicle University  Diyarbakir 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