{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T06:14:36Z","timestamp":1695622476526},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T00:00:00Z","timestamp":1455753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A woman with twin pregnancy had a gradual decline in anti\u2010thrombin (AT) activity from 72% at gestational week (GW) 29<jats:sup>\u20133\/7<\/jats:sup>, to 53% at GW31<jats:sup>\u20132\/7<\/jats:sup>, and to 41% at GW32<jats:sup>\u20132\/7<\/jats:sup>, at which time hypertension (148\/90 mmHg) and proteinuria (protein\u2010to\u2010creatinine ratio [P\/Cr], 0.79\u00a0mg\/mg) developed in the presence of normal platelet count (159 \u00d7 10<jats:sup>9<\/jats:sup>\/L) and serum aspartate aminotransferase\/lactate dehydrogenase (22\/164 IU\/L). AT product was given three times to maintain AT activity &gt;50% and blood pressure was maintained below 155\/95 mmHg with no treatment, but generalized edema with a weekly weight gain of 4.9 kg and increased proteinuria (to P\/Cr, 7.6\u00a0mg\/mg) required cesarean section at GW33<jats:sup>\u20133\/7<\/jats:sup>. This case highlights the occurrence of pregnancy\u2010induced AT deficiency alone in the absence of any other abnormality, including hypertension, proteinuria, or thrombocytopenia. Measurement of AT activity was considered helpful for determination of the appropriate time for delivery in this patient.<\/jats:p>","DOI":"10.1111\/jog.12951","type":"journal-article","created":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T22:10:44Z","timestamp":1455833444000},"page":"719-721","source":"Crossref","is-referenced-by-count":0,"title":["Isolated pregnancy\u2010induced anti\u2010thrombin deficiency in a woman with twin pregnancy"],"prefix":"10.1111","volume":"42","author":[{"given":"Kosuke","family":"Kawabata","sequence":"first","affiliation":[{"name":"Department of Obstetrics Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoru","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisanori","family":"Minakami","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12282"},{"key":"e_1_2_5_3_1","volume-title":"Hypertension in Pregnancy: The Management of Hypertensive Disorders During Pregnancy (NICE Clinical Guidelines, No. 107)","author":"Royal College of Obstetricians and Gynaecologists","year":"2010"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80190-1"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm.2010.049"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)70396-4"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641955.2013.792346"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040563"},{"key":"e_1_2_5_9_1","first-page":"188","article-title":"Antithrombin and its inherited deficiency states","volume":"34","author":"Boven HH","year":"1997","journal-title":"Semin Hematol"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116133"},{"key":"e_1_2_5_11_1","first-page":"141","article-title":"Antithrombin activity, platelet count, hemoglobin concentration and hematocrit value determined immediately before vaginal delivery among healthy women","volume":"87","author":"Morikawa M","year":"2012","journal-title":"Hokkaido Igaku Zasshi"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2002.810907.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.6.876"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12419"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12470"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-993902"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12951","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12951","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.12951","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:02:52Z","timestamp":1695542572000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.12951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,18]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/jog.12951"],"URL":"https:\/\/doi.org\/10.1111\/jog.12951","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,18]]}}}