{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:34:08Z","timestamp":1791326048330,"version":"4.3.1"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T00:00:00Z","timestamp":1455753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Endometriosis (EM) is a hormone\u2010dependent chronic inflammatory disease, usually accompanied by a high level of localized estrogen and abnormal levels of cytokines, which are regulated by GATA\u20103 in lymphocytes. This study aimed to investigate the role of estrogen on GATA\u20103 expression and the relationship between GATA\u20103 and cytokine response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Endometrial tissues collected from 20 patients who underwent laparoscopic or open surgery were used. Immunohistochemistry, quantitative polymerase chain reaction, <jats:styled-content style=\"fixed-case\">Western blot<\/jats:styled-content> analysis, cell transfection, estrogen treatments and enzyme\u2010linked immunosorbent assays were performed to evaluate the effects of estrogen on GATA\u20103 expression and the relationship between estrogen\u2010induced GATA\u20103 and the Th2 immune status of EM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Estrogen regulated the expression of GATA\u20103 in a dose and time\u2010dependent manner. GATA\u20103 was relocated from the cytoplasm to the nucleus. Estrogen and GATA\u20103 regulated Th2 cytokine expression in eutopic endometrial cells, including interleukin (IL)\u20106, IL\u20108 and IL\u201010. Moreover, interferon\u2010\u03b3 and IL\u20102 were highly expressed in the GATA\u20103 knockdown groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In summary, GATA\u20103 was induced by estrogen and may promote the occurrence and development of EM by regulating the secretion of cytokines in the eutopic endometrial cells of EM patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12957","type":"journal-article","created":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T22:13:13Z","timestamp":1455833593000},"page":"669-677","source":"Crossref","is-referenced-by-count":44,"title":["Evaluation of estrogen in endometriosis patients: Regulation of GATA\u20103 in endometrial cells and effects on Th2 cytokines"],"prefix":"10.1111","volume":"42","author":[{"given":"Peng","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Shengjing Hospital of China Medical University  Shenyan 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