{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T11:25:23Z","timestamp":1778757923624,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T00:00:00Z","timestamp":1456876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Science, Sports, and Culture of Japan","doi-asserted-by":"crossref","award":["26462468"],"award-info":[{"award-number":["26462468"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Science, Sports, and Culture of Japan","doi-asserted-by":"crossref","award":["25462546"],"award-info":[{"award-number":["25462546"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Women with pre\u2010eclampsia (PE), placenta previa (PP), placental abruption (PA), and placental mesenchymal dysplasia (PMD) have been described as having placental permeability dysfunction. This study was performed to determine whether occult fetomaternal hemorrhage (FMH) is common in women with such complications and in women with non\u2010reassuring fetal status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010one antenatal and 39 postnatal blood samples were obtained from 46 women, including 11 with placental permeability dysfunction (5, 3, 2, and 1 with PE, PP, PA, and PMD, respectively) and 35 controls without such complications. To estimate the amount of fetal red blood cells, flow cytometry was performed using the fetal cell count system with two antibodies against fetal hemoglobin and carbonic anhydrase and the \u03b2\u2010\u03b3 system with two monoclonal antibodies against hemoglobin \u03b2\u2010chain and hemoglobin \u03b3\u2010chain. A diagnosis of FMH was made when the fraction size of the isolated cell population on scatter plots expressing fetal hemoglobin alone or hemoglobin \u03b3\u2010chain alone accounted for \u22650.02% of the total cell population on scatter plots.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FMH was identified in five women, including one each with PE, PA, PP, PMD, and no complications. Thus, the prevalence rate of FMH was significantly higher in women with complications than in controls (36% [4\/11] vs 2.9% [1\/35], respectively, <jats:italic>P<\/jats:italic> = \u20050.009). The FMH occurrence rate did not differ between women with and without non\u2010reassuring fetal status (7.7% [1\/13] vs 12% [4\/33], respectively, <jats:italic>P<\/jats:italic> = \u20051.000).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The risk of fetal red blood cells trafficking into the maternal circulation may be increased in women complicated with PE, PA, PP, and PMD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12959","type":"journal-article","created":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T03:17:06Z","timestamp":1456975026000},"page":"632-639","source":"Crossref","is-referenced-by-count":17,"title":["Occult fetomaternal hemorrhage in women with pathological placenta with respect to permeability"],"prefix":"10.1111","volume":"42","author":[{"given":"T.","family":"Umazume","sequence":"first","affiliation":[{"name":"Department of Perinatal Medicine Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Perinatal Medicine Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Department of Perinatal Medicine Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Perinatal Medicine Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Perinatal Medicine Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Perinatal Medicine Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Masauzi","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science, Faculty of Health Sciences Hokkaido University  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Minakami","sequence":"additional","affiliation":[{"name":"Department of Perinatal Medicine Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,2]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"323","article-title":"Massive fetomaternal hemorrhage: Manitoba experience","volume":"83","author":"DeAlmeida V","year":"1994","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"F405","DOI":"10.1136\/archdischild-2011-300820","article-title":"Demographics, clinical characteristics and outcomes of neonates diagnosed with fetomaternal haemorrhage","volume":"97","author":"Stroustrup A","year":"2012","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/jmf.13.2.128.132"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2014.05.010"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1990.30490273444.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000271212.66040.70"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2004.01.005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719113492209"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.03.027"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-6-38"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1309\/RV45HRD53YQ2YFTP"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.345"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2008.04.004"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2012.01143.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12419"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.02.029"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2009.063"},{"key":"e_1_2_7_19_1","first-page":"166","article-title":"Serological conditions and occurrence in normal adults and normal pregnant and post partum women with particular reference to foeto\u2010maternal hemorrhage","volume":"15","author":"Christensen J","year":"1968","journal-title":"Dan Med Bull"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-011-2028-1"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(99)90000-0"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12757"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12959","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12959","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.12959","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:02:36Z","timestamp":1695542556000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.12959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,2]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/jog.12959"],"URL":"https:\/\/doi.org\/10.1111\/jog.12959","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,2]]}}}