{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:14:07Z","timestamp":1780344847479,"version":"3.54.1"},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T00:00:00Z","timestamp":1456272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess whether pain experienced during embryo transfer (ET) is associated with the chance of clinical pregnancy in assisted reproductive technology cycles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective observational study of 284 women conducted between<jats:styled-content style=\"fixed-case\">July<\/jats:styled-content>2011 and<jats:styled-content style=\"fixed-case\">January<\/jats:styled-content>2014. Women under 40 years undergoing<jats:italic>in vitro<\/jats:italic>fertilization\/intracytoplasmic sperm injection (IVF\/ICSI) cycles followed by fresh\/frozen ET were recruited. Pain was measured using a 100\u2010mm visual analogue scale. Several factors relating to both pain and also the nature of the ET procedure were recorded: use of vulsellum, uterine contractility, depth of ET, duration of ET catheter insertion, urgency of micturition, psychological profile tests, salivary \u03b1\u2010amylase and salivary cortisol. Primary outcome was the achievement of clinical pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women who experienced pain during ET had a significantly lower clinical pregnancy rate compared with women who did not (42.2% vs 53.8%;<jats:italic>P<\/jats:italic>= 0.03). Non\u2010pregnant women also had significantly higher pain scores compared with pregnant women (10.3 vs 6.4;<jats:italic>P<\/jats:italic>= 0.01). Pain was independent of &gt;20 variables relating to (i) the nature of the ET procedure; (ii) psychological testing; and (iii) potential confounding factors inherent to IVF\/ICSI. On binary logistic regression analysis, pain was an independent predictor for the chance of clinical pregnancy (OR, 0.59; 95%CI: 0.37\u20100.94;<jats:italic>P<\/jats:italic>= 0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pain during ET is independently associated with the chance of clinical pregnancy. The underlying mechanism could involve factors other than nature of the ET and the psychological state of the patient, and warrants further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12962","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T08:36:26Z","timestamp":1456475786000},"page":"684-693","source":"Crossref","is-referenced-by-count":15,"title":["Pain during embryo transfer is independently associated with clinical pregnancy in fresh\/frozen assisted reproductive technology cycles"],"prefix":"10.1111","volume":"42","author":[{"given":"Sotirios H.","family":"Saravelos","sequence":"first","affiliation":[{"name":"Assisted Reproductive Technology Unit Prince of Wales Hospital, Chinese University of Hong Kong Shatin New Territories Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice WY.","family":"Wong","sequence":"additional","affiliation":[{"name":"Assisted Reproductive Technology Unit Prince of Wales 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