{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:00:55Z","timestamp":1791925255430,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T00:00:00Z","timestamp":1458000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Seoul National University Bundang Hospital Research Fund","award":["13-2014-004"],"award-info":[{"award-number":["13-2014-004"]}]},{"name":"Korea Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea","award":["HI 14C1798"],"award-info":[{"award-number":["HI 14C1798"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The purpose of this study is to determine whether proinflammatory cytokines and matrix metalloproteinases (MMPs) in amniotic fluid (AF), alone or in combination with clinical risk factors, can predict spontaneous preterm delivery (SPTD) at &lt; 34 weeks in women with cervical insufficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study included 57 consecutive singleton pregnant women (17\u201328 gestational weeks) with cervical insufficiency who underwent amniocentesis. AF was assayed for five cytokines (interleukin [IL]\u20106, IL\u20108, monocyte chemotactic protein\u20101, macrophage inflammatory protein [MIP]\u20101\u03b1, and MIP\u20101\u03b2) and five MMPs (MMP\u20101, MMP\u20102, MMP\u20103, MMP\u20108, and MMP\u20109) using multiplex immunoassay kits. The primary outcome measure was SPTD at &lt; 34 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The AF concentrations of MMP\u20101, MMP\u20103, MMP\u20108, MMP\u20109, IL\u20106, IL\u20108, MIP\u20101\u03b1 and MIP\u20101\u03b2 were significantly higher in women with SPTD at &lt; 34 weeks. Women who had SPTD at &lt; 34 weeks were younger, had significantly more advanced cervical dilatation at presentation and a higher rate of positive AF cultures. Using stepwise regression analysis, a combined prediction model was developed that included maternal age, cervical dilatation at presentation, AF MMP\u20101 and AF MMP\u20108 (area under the curve [AUC] 0.951). The AUC for this model was significantly greater than for any single protein alone in AF or for each of the clinical risk factors alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A model combining proteins in AF and clinical factors can improve the accuracy of risk prediction for preterm birth and this combination is more accurate than each of the biomarkers alone in women with cervical insufficiency.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12976","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T01:02:11Z","timestamp":1458349331000},"page":"776-783","source":"Crossref","is-referenced-by-count":29,"title":["Prediction of spontaneous preterm birth in women with cervical insufficiency: Comprehensive analysis of multiple proteins in amniotic fluid"],"prefix":"10.1111","volume":"42","author":[{"given":"Seung Mi","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul 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