{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:25:46Z","timestamp":1759047946519},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T00:00:00Z","timestamp":1462406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401272"],"award-info":[{"award-number":["81401272"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to investigate the therapeutic effects and mechanism of Wharton jelly\u2010derived mesenchymal stem cells (WJ\u2010MSC) in a spontaneous\u2010abortion rat model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An abortion model was established using intravenous injection of bromocriptine. WJ\u2010MSC were isolated and cultured from Wharton jelly of the human umbilical cord. The pathologic changes of placenta decidual tissues were observed after hematoxylin\u2013eosin staining. The embryo absorption rate was counted. The protein and mRNA levels of interleukin (IL)\u201010, interferon (IFN)\u2010\u03b3 and IL\u201017 in each group were tested by enzyme\u2010linked immunosorbent assay, Western blot and quantitative real\u2010time polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After bromocriptine injection, decidual cells degenerated and the connections between them loosened. Furthermore, some of the decidual cells were necrotic and the nuclei had disappeared. However, the transplantation of a large population of WJ\u2010MSC prevented these damages from occurring. The changes of levels of IL\u201010, IFN\u2010\u03b3 and IL\u201017 in serum and placenta decidual tissues induced by bromocriptine were well restored by a high, but not a low, dose of WJ\u2010MSC engraft.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>WJ\u2010MSC can ameliorate early pregnancy loss. The mechanism may be related to its upregulation of IL\u201010 and downregulation of IFN\u2010\u03b3 and IL\u201017.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12984","type":"journal-article","created":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T06:36:47Z","timestamp":1462430207000},"page":"972-982","source":"Crossref","is-referenced-by-count":12,"title":["Therapeutic effects of Wharton jelly\u2010derived mesenchymal stem cells on rat abortion models"],"prefix":"10.1111","volume":"42","author":[{"given":"Xiaojing","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Affiliated Hospital of Nantong University  Nantong China"},{"name":"Department of Gynecology Tumor Hospital of Nantong  Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Affiliated Hospital of Nantong University  Nantong 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