{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:51:30Z","timestamp":1787637090017,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,4,14]],"date-time":"2016-04-14T00:00:00Z","timestamp":1460592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Placental abruption is a severe obstetric complication of pregnancy that can cause disseminated intravascular coagulation and progress to massive post\u2010partum hemorrhage. Coagulation disorder due to extreme consumption of fibrinogen is considered the main pathogenesis of disseminated intravascular coagulation in patients with placental abruption. The present study sought to determine if the pre\u2010delivery fibrinogen level could predict adverse maternal or neonatal outcomes in patients with placental abruption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective medical chart review was conducted in a center for maternal, fetal, and neonatal medicine in Japan with 61 patients with placental abruption. Fibrinogen levels prior to delivery were collected and evaluated for the prediction of maternal and neonatal outcomes. The main outcome measures for maternal outcomes were disseminated intravascular coagulation and hemorrhage, and the main outcome measures for neonatal outcomes were Apgar score at 5 min, umbilical artery pH, and stillbirth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The receiver\u2013operator curve and multivariate logistic regression analyses indicated that fibrinogen significantly predicted overt disseminated intravascular coagulation and the requirement of \u22656 red blood cell units, \u226510 fresh frozen plasma units, and \u226520 fresh frozen plasma units for transfusion. Moderate hemorrhage occurred in 71.5% of patients with a decrease in fibrinogen levels to 155 mg\/dL. Fibrinogen could also predict neonatal outcomes. Umbilical artery pH &lt; 7.00 occurred in 77.1% of patients with a decrease in fibrinogen levels to\u00a0\u2264\u00a0250 mg\/dL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pre\u2010delivery fibrinogen can predict adverse maternal as well as neonatal outcomes with placental abruption. \u00a9 2016 Japan Society of Obstetrics and Gynecology<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12988","type":"journal-article","created":{"date-parts":[[2016,4,14]],"date-time":"2016-04-14T05:26:44Z","timestamp":1460611604000},"page":"796-802","source":"Crossref","is-referenced-by-count":47,"title":["Pre\u2010delivery fibrinogen predicts adverse maternal or neonatal outcomes in patients with placental abruption"],"prefix":"10.1111","volume":"42","author":[{"given":"Liangcheng","family":"Wang","sequence":"first","affiliation":[{"name":"Center for Maternal, Fetal and Neonatal Medicine Saitama Medical Center, Saitama Medical University Kawagoe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigetaka","family":"Matsunaga","sequence":"additional","affiliation":[{"name":"Center for Maternal, Fetal and Neonatal Medicine Saitama Medical Center, Saitama Medical University Kawagoe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Mikami","sequence":"additional","affiliation":[{"name":"Center for Maternal, Fetal and Neonatal Medicine Saitama Medical Center, Saitama Medical University Kawagoe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Takai","sequence":"additional","affiliation":[{"name":"Center for Maternal, Fetal and Neonatal Medicine Saitama Medical Center, Saitama Medical University Kawagoe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuo","family":"Terui","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Saitama Medical Center, Saitama Medical University Kawagoe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Seki","sequence":"additional","affiliation":[{"name":"Center for Maternal, Fetal and Neonatal Medicine Saitama Medical Center, Saitama Medical University Kawagoe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125246"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.17.1646"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/153.4.332"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2009.04.002"},{"key":"e_1_2_7_6_1","first-page":"385","article-title":"Abruptio placentae; 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