{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:45:51Z","timestamp":1785797151240,"version":"3.56.0"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,4,17]],"date-time":"2016-04-17T00:00:00Z","timestamp":1460851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Agnathia\u2013otocephaly or agnathia\u2010sinotia\u2010microstomy syndrome is the most severe malformation affecting the first branchial arch. It is a rare congenital anomaly characterized by absence of the lower jaw and abnormal ear positioning. Prenatal diagnosis is possible on conventional 2\u2010D ultrasound in the second trimester. Three\u2010dimensional ultrasound enhances detection of abnormal facial phenotype, especially in surface rendering mode. In addition, 3\u2010D volume datasets are used to produce a physical model of the anomaly. We present a case of second trimester ultrasound diagnosis of agnathia\u2013otocephaly associated with limb deformities. A physical model produced using 3\u2010D ultrasound volume datasets facilitated better understanding of this congenital malformation, and improvement of parental counselling and management by the multispecialist team.<\/jats:p>","DOI":"10.1111\/jog.13014","type":"journal-article","created":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T02:22:41Z","timestamp":1460946161000},"page":"1016-1020","source":"Crossref","is-referenced-by-count":14,"title":["Prenatal diagnosis and physical model reconstruction of agnathia\u2013otocephaly with limb deformities (absent ulna, fibula and digits) following maternal exposure to oxymetazoline in the first trimester"],"prefix":"10.1111","volume":"42","author":[{"given":"Gl\u00e1ucia Aparecida","family":"Menezes","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics Federal University of Latin American Integration (UNILA)  Foz do Iguacu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Araujo J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Paulista School of Medicine \u2013 Federal University of S\u00e3o Paulo (EPM\u2010UNIFESP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Arts and Design Pontif\u00edcal Catholic University (PUC Rio)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Belmonte","sequence":"additional","affiliation":[{"name":"Department of Arts and Design Pontif\u00edcal Catholic University (PUC Rio)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Tonni","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Guastalla Civil Hospital  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heron","family":"Werner","sequence":"additional","affiliation":[{"name":"Radiology Clincial Diagnostic Imaging (CDPI)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/15513811003796946"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2011.11.033"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2010.09.002"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00160-5"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1159\/000353727","article-title":"Otocephaly\u2010dysgnathia complex: Description of four cases and confirmation of the role of OTX2","volume":"4","author":"Patat O","year":"2013","journal-title":"Mol Syndromol"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7619"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-006-0040-5"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws427"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200528080-00005"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320140411"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31335"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10396-014-0550-z"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2006.25.4.533"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970140616"},{"key":"e_1_2_5_16_1","first-page":"238","article-title":"Two sporadic cases of amelia\/phocomelia with similar phenotype: Rare and unusually symmetrical form of FFU dysostosis or separate entity?","volume":"2","author":"Kardon NB","year":"1986","journal-title":"Am J Med Genet Suppl"},{"key":"e_1_2_5_17_1","first-page":"377","article-title":"Agnathia\u2010otocephaly: Prenatal diagnosis by two\u2010 and three\u2010dimensional ultrasound and magnetic resonance imaging","volume":"16","author":"Hisaba WJ","year":"2014","journal-title":"Case report. 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