{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:16:46Z","timestamp":1788491806400,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T00:00:00Z","timestamp":1464220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Although there are various hormone therapies, including gonadotropin\u2010releasing hormone agonist, danazol, levonorgestrel\u2010releasing intrauterine system, dienogest, and low\u2010dose estrogen progestin, no consensus opinion has been reached in terms of which medication should be used and for how long it should be administered. We aimed to determine whether dienogest or goserelin is the better postoperative therapy to prevent recurrence of endometriosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective cohort randomized study were conducted, including 198 patients diagnosed as having endometriosis. A total of 111 patients were randomly assigned into two groups: the dienogest\u2010administered group (<jats:italic>n<\/jats:italic>\u00a0=\u00a056) and the goserelin\u2010administered group (<jats:italic>n<\/jats:italic>\u00a0=\u00a055). Patients were followed for 24 months after laparoscopic surgery. Those who gave consent but desired no postoperative therapy were assigned to the non\u2010treatment group (<jats:italic>n<\/jats:italic>\u00a0=\u00a079). Recurrence, side\u2010effects, degrees of menstrual pain and chronic pelvic pain measured by the Visual Analogue Scale were compared among the three groups: the dienogest, goserelin, and non\u2010treatment groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant difference was observed in the postoperative recurrence rate between the dienogest and goserelin groups. No significant difference was found in the recurrence rate between the goserelin group and non\u2010treatment group; however, a significant difference was found in the recurrence rate between the dienogest group and the non\u2010treatment group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.027). Menstrual pain and chronic pelvic pain were significantly improved in both treatment groups. Side\u2010effects were markedly observed in the goserelin group as compared with the dienogest group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dienogest is available for prolonged administration of more than 6 months, so it is more useful than goserelin, which is available only for short\u2010term administration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13023","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T08:09:00Z","timestamp":1464250140000},"page":"1152-1158","source":"Crossref","is-referenced-by-count":53,"title":["Dienogest compared with gonadotropin\u2010releasing hormone agonist after conservative surgery for endometriosis"],"prefix":"10.1111","volume":"42","author":[{"given":"Yotaro","family":"Takaesu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Tokyo Medical University  Tokyo Japan"},{"name":"St. John's Society Sakuramachi Hospital  Tokyo 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