{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:28Z","timestamp":1787015548138,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T00:00:00Z","timestamp":1466467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of this study was to investigate the potential association between neural tube defects and paraoxonase\u20101 activity in amniotic fluid. We studied total oxidant status, total antioxidant capacity, paraoxonase\u20101 activity and thyroid hormone amniotic fluid concentration in fetuses with neural tube defects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The present study was performed at the Department of Obstetrics and Gynaecology and the Department of Clinical Biochemistry of Dicle University between September 2011 and June 2013. The study group included 37 amniotic fluid samples from pregnant women (16\u201320 weeks of gestation) with fetuses affected by neural tube defects. The control group consisted of 36 pregnant women who were diagnosed with a high\u2010risk pregnancy according to first or second trimester aneuploidy screening and were later confirmed on amniocentesis to have genetically normal fetuses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Amniotic fluid paraoxonase\u20101 activity and total oxidant status were significantly higher (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.023,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.029, respectively) whereas free T4 was significantly lower (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.022) in fetuses with neural tube defects compared with control subjects. In fetuses with neural tube defects, amniotic fluid paraoxonase\u20101 activity correlated positively with total oxidant status (r = 0.424**,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.010), and amniotic fluid total antioxidant capacity correlated positively with free t4 (r = 0.381*,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.022).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the first study in the literature to show an association between paraoxonase\u20101 activity and thyroid hormone concentration and neural tube defects.<\/jats:p>\n                  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