{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:44:33Z","timestamp":1762101873669},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T00:00:00Z","timestamp":1465344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"MEXT KAKENHI","award":["24119004"],"award-info":[{"award-number":["24119004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We conducted a retrospective analysis of summary medical reports of children diagnosed with cerebral palsy (CP) to identify clinical features of antenatal onset of CP secondary to transient ischemia <jats:italic>in utero<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The 658 brief summary reports available in the Japan Obstetric Compensation System for Cerebral Palsy were screened, and we identified cases of singleton pregnancy, delivered at gestational age \u2265 33 weeks and those with cord blood gas pH\u00a0\u2265\u00a07.20. Of the 137 cases identified, 84 were excluded for the following reasons: no evidence of ischemic brain lesion, clear post\u2010natal causative factor of CP, presence of a congenital condition, and sentinel hypoxic event, such as uterine rupture. The demographic profiles of the 53 cases included in our analysis were compared to identify those with and without an abnormal variability in fetal heart rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between\u2010group comparison identified an association between abnormal heart rate variability and a lower Apgar score at 1 min (2 vs 6; <jats:italic>P<\/jats:italic> &lt; 0.001) and 5 min (5.5 vs 8; <jats:italic>P<\/jats:italic> = 0.002), and more frequent episodes of fetal movement loss (41% vs 10%; <jats:italic>P<\/jats:italic> = 0.027). An hypoxic event\u00a0\u2264\u00a01 week before delivery was more likely to be associated with abnormal heart rate variability (89%) and low Apgar score (82%), while events at\u00a0&gt;\u00a01 week were associated with development of polyhydramnios (44%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>In utero<\/jats:italic> transient ischemic events can contribute to term or near\u2010term CP. Careful follow\u2010up is recommended for fetuses with a history of fetal movement loss, abnormal variability in heart rate, and polyhydramnios of unknown causes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13046","type":"journal-article","created":{"date-parts":[[2016,6,9]],"date-time":"2016-06-09T03:56:43Z","timestamp":1465444603000},"page":"1297-1303","source":"Crossref","is-referenced-by-count":6,"title":["Analysis of antenatal\u2010onset cerebral palsy secondary to transient ischemia <i>in utero<\/i> using a national database in Japan"],"prefix":"10.1111","volume":"42","author":[{"given":"Kotaro","family":"Fukushima","sequence":"first","affiliation":[{"name":"Department of Obstetrics Fukuoka Children's Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichi","family":"Morokuma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kyushu University Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzo","family":"Kitadai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Fukuoka Children's Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Tazaki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Fukuoka Children's Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Sumie","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Fukuoka Children's Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoyuki","family":"Nakanami","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Fukuoka Children's Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Ushiro","sequence":"additional","affiliation":[{"name":"Division of Patient Safety Kyushu University Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology International University of Health and Welfare Hospital  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyomi","family":"Tsukimori","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Fukuoka Children's Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198607103150202"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.05.034"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2012.01.007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsb035364"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767050903019619"},{"key":"e_1_2_7_7_1","unstructured":"The Japan Council for Quality Health Care.Guide to the Japan Obstetric Compensation System for Cerebral Palsy. [Cited 31 October2015.] Available from URL:http:\/\/sanka\u2010hp.jcqhc.or.jp\/documents\/english\/pdf\/tirashi_eng.pdf"},{"key":"e_1_2_7_8_1","unstructured":"The Japanese Social Welfare System Criteria for Determining Degree of Disabilities. [Cited 30 June2015.] Available from URL:http:\/\/www.sanka\u2010hp.jcqhc.or.jp\/documents\/exam\/pdf\/hosyoutaisyou.pdf"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2014.01.001"},{"key":"e_1_2_7_10_1","unstructured":"The Japan Council for Quality Health Care.Brief report on the cause of cerebral palsy. 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