{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:06:16Z","timestamp":1783469176067,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T00:00:00Z","timestamp":1467158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It is frequently difficult to distinguish multiple primary carcinomas from single primary carcinoma with metastasis. Here, we report a case of synchronous endometrioid adenocarcinomas that independently occurred in the uterine cervix and corpus. A 47\u2010year\u2010old woman complaining of genital bleeding was preoperatively diagnosed with cervical adenocarcinoma with an endometrial lesion. On surgical treatment, two separate malignant lesions bearing endometrioid adenocarcinoma were identified in the uterine cervix and cavity. Although both lesions expressed the same type of human papillomavirus (HPV) gene, type 16, microscopic continuity was not observed. Furthermore, we detected a critical difference in <jats:italic>PTEN<\/jats:italic> mutation between the tumors and finally diagnosed this case as multiple primary cancers. This is the first report to show multiple primary endometrioid adenocarcinomas simultaneously arising in the uterine cervix and corpus. Considering the rarity of this case, the coexistence of HPV suggests its possible involvement in the carcinogenesis of the endometrioid adenocarcinomas.<\/jats:p>","DOI":"10.1111\/jog.13049","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T07:08:06Z","timestamp":1467184086000},"page":"1390-1394","source":"Crossref","is-referenced-by-count":6,"title":["Synchronous endometrioid adenocarcinomas in the uterine cervix and corpus"],"prefix":"10.1111","volume":"42","author":[{"given":"Takeshi","family":"Obata","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanazawa University Graduate School of Medical Science  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanazawa University Graduate School of Medical Science  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunari","family":"Mizumoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanazawa University Graduate School of Medical Science  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanazawa University Graduate School of Medical Science  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Takakura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanazawa University Graduate School of Medical Science  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanazawa University Graduate School of Medical Science  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,29]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1358","article-title":"Multiple primary malignant tumors: A survey of the literature and statistical study","volume":"16","author":"Warren S","year":"1932","journal-title":"Am J Cancer"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(85)80210-0"},{"key":"e_1_2_6_4_1","first-page":"125","volume-title":"Atlas of Tumor Pathology","author":"Scully RE","year":"1998"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-72-5-1039"},{"key":"e_1_2_6_6_1","first-page":"1883","article-title":"Alterations of the p53 tumor suppressor gene and its association with activation of the c\u2010K\u2010ras\u20102 protooncogene in premalignant and malignant lesions of the human uterine endometrium","volume":"53","author":"Enomoto T","year":"1993","journal-title":"Cancer Res."},{"key":"e_1_2_6_7_1","first-page":"3935","article-title":"Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies","volume":"57","author":"Tashiro H","year":"1997","journal-title":"Cancer Res."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2010.03.001"},{"key":"e_1_2_6_9_1","first-page":"197","article-title":"Human papillomavirus 18\u2010immortalized endocervical cells with in vitro cytokeratin expression characteristics of adenocarcinoma","volume":"83","author":"Yokoyama M","year":"1994","journal-title":"Obstet. Gynecol."},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2009.03367.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2008.056101"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800316"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2014.55"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29651"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(95)90171-X"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-013-0597-5"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.13049","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.13049","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.13049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T12:42:58Z","timestamp":1696509778000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.13049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,29]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/jog.13049"],"URL":"https:\/\/doi.org\/10.1111\/jog.13049","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,29]]}}}