{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T03:28:19Z","timestamp":1772249299767,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T00:00:00Z","timestamp":1467244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>There is a paucity of information on vitamin D status of women with twin pregnancy and their newborns. This case\u2013control study compared maternal and neonatal vitamin\u2010D status in twin versus singleton pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects included 50 women with twin pregnancy delivering at &gt;28 weeks and 50 gestational\u2010age\u2010matched women with singleton pregnancy delivering during the same period. Maternal and neonatal serum 25\u2010hydroxy vitamin D [25(OH)D] was compared between the two groups using the independent Student's <jats:italic>t<\/jats:italic>\u2010test on log values. Serum albumin\u2010adjusted calcium, inorganic phosphate, and intact parathormone levels were also compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Maternal vitamin\u2010D deficiency (VDD; serum 25(OH)D &lt; 30 nmol\/L) was present in 90% of twin and 88% of singleton pregnancies. The prevalence of neonatal VDD was 89% in twin and 74% in singleton pregnancies (<jats:italic>P\u00a0=<\/jats:italic>\u00a00.03). Maternal serum 25(OH)D was lower in the twin group as compared to the singleton group (14.3\u00a0\u00b1\u00a010.47 vs 18.5\u00a0\u00b1\u00a012.36 nmol\/L; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). Mean serum calcium, intact parathormone, and inorganic phosphate were comparable between the women in the two groups. Maternal and neonatal 25(OH)D showed positive correlation in the two groups (<jats:italic>P<\/jats:italic> &lt; 0.001). Mean cord blood 25(OH)D was significantly lower in the twins than in singleton newborns (14.8\u00a0\u00b1\u00a012.63 vs 22.6\u00a0\u00b1\u00a016.68 nmol\/L; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002). The difference persisted even after adjustment for birthweights and maternal serum 25(OH)D. Mean serum calcium was significantly lower in the twins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Twin newborns and their mothers have higher VDD as compared to singleton newborns and their mothers in the VDD population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13060","type":"journal-article","created":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T09:06:54Z","timestamp":1467277614000},"page":"1250-1257","source":"Crossref","is-referenced-by-count":16,"title":["Maternal and neonatal vitamin\u2010D status in twin versus singleton pregnancies"],"prefix":"10.1111","volume":"42","author":[{"given":"Deepti","family":"Goswami","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reena","family":"Rani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alpana","family":"Saxena","sequence":"additional","affiliation":[{"name":"Department of Biochemistry  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika Sethi","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Dietetics Maulana Azad Medical College &amp; Lok Nayak Hospital  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swaraj","family":"Batra","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishnubhatla","family":"Sreenivas","sequence":"additional","affiliation":[{"name":"Department of Biostatistics All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025239"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2012.02.001"},{"key":"e_1_2_6_4_1","first-page":"221","article-title":"Iron stocks and risk of anemia in twins","volume":"66","author":"Ben Miled S","year":"1989","journal-title":"Arch Inst Pasteur Tunis"},{"key":"e_1_2_6_5_1","first-page":"168","article-title":"A case\u2013control study of 1253 twin pregnancies from a 1982\u20131987 perinatal data base","volume":"75","author":"Spellacy WN","year":"1990","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f1169"},{"key":"e_1_2_6_7_1","unstructured":"Royal College of Obstetricians and Gynaecologists.Vitamin D in pregnancy. 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