{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:26:08Z","timestamp":1778498768072,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T00:00:00Z","timestamp":1477526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Malignant transformation of epidermal cyst is rare, with most cases arising in the head and neck. Here, we report a case of squamous cell carcinoma arising from a longstanding epidermal cyst in the right vulva of a 65\u2010year\u2010old woman. The patient presented with a sudden increase in size of the cyst over 6 weeks to the size of a golf ball. Excisional biopsy and histology indicated moderately differentiated squamous cell carcinoma within an epidermal cyst (FIGO stage IB). Strong p16 immunopositivity was also demonstrated and the potential significance of this is discussed. Limited right hemivulvectomy and right groin node dissection were performed.<\/jats:p>","DOI":"10.1111\/jog.13091","type":"journal-article","created":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T07:25:59Z","timestamp":1477553159000},"page":"1623-1626","source":"Crossref","is-referenced-by-count":18,"title":["Squamous cell carcinoma arising from a vulval epidermal cyst"],"prefix":"10.1111","volume":"42","author":[{"given":"Shirley","family":"Sze","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Diana, Princess of Wales Hospital  Grimsby, Lincolnshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Richmond","sequence":"additional","affiliation":[{"name":"Department of Pathology Hull Royal Infirmary  Hull, Yorkshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Bickers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Diana, Princess of Wales Hospital  Grimsby, Lincolnshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arabinda","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Diana, Princess of Wales Hospital  Grimsby, Lincolnshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199904000-00012"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2010.01.001"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2001.04400.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015458.2002.11679293"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59980300466-2"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.03130.x"},{"key":"e_1_2_5_8_1","first-page":"482","article-title":"Squamous cell carcinoma arising from an epidermal cyst","volume":"13","author":"Chiu MY","year":"2007","journal-title":"Hong Kong Med J"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.12968\/hmed.2007.68.8.24499"},{"key":"e_1_2_5_10_1","first-page":"46","article-title":"Squamous cell carcinoma arising from an epidermal inclusion cyst: A case report","volume":"2","author":"Zaidi S","year":"2010","journal-title":"N Am J Med Sci"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/2000656X.2012.677403"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103293441306"},{"key":"e_1_2_5_13_1","first-page":"279","article-title":"Squamous cell carcinoma arising in an epidermal inclusion cyst","volume":"25","author":"Chin\u2010Yew L","year":"2002","journal-title":"Chang Gung Med J"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pap.0000201828.92719.f3"},{"key":"e_1_2_5_15_1","first-page":"119","article-title":"Human papilloma virus (HPV) in head and neck region: Review of literature","volume":"29","author":"Mannarini L","year":"2009","journal-title":"Acta Otorhinolaryngol Ital"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.13091","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.13091","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.13091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:39:49Z","timestamp":1695573589000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.13091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,27]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/jog.13091"],"URL":"https:\/\/doi.org\/10.1111\/jog.13091","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,27]]}}}