{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:12:29Z","timestamp":1790223149407,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T00:00:00Z","timestamp":1474329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare ormeloxifene with combined oral contraceptive (COC) in abnormal uterine bleeding (AUB) due to leiomyoma (AUB\u2010L).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty women with AUB\u2010L were randomized after informed consent and institute ethics clearance. Group I (n\u00a0=\u00a025) was given ormeloxifene (a SERM i.e. selective estrogen receptor modulator) 60\u00a0mg twice per week and group II (n\u00a0=\u00a025) was given COC (ethinyl estradiol 30\u00a0\u03bcg with desogestrel 150\u00a0\u03bcg) on days 1\u201321 for 6\u00a0months. Menstrual blood loss was assessed on pictorial blood loss assessment chart (PBAC) score and leiomyoma volume was assessed on ultrasound. Fibroids were classified according to FIGO\u2010PALM\u2010COEIN classification for AUB where leiomyomas were further sub\u2010classified as types 0 to 8 according to their location. Follow up was done at 1, 3, 6 and 9\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean PBAC score reduced by 81% with ormeloxifene (group I) compared with 43.8% for COC (group II). After 6\u00a0months, 18 patients (72%) in group I had PBAC score in the non\u2010menorrhagic range (&lt;100) compared with only two (8%) in group II. In group I, PBAC score in FIGO\u2010PALM\u2010COEIN leiomyoma types 2, 3, 4, 5, 6 reduced by 90.2%, 82.5%, 93.3%, 56.4% and 100%, respectively and 14 (56%) developed amenorrhea; compared with reduction of 64%, 27.5%, 25.9% in types 4, 5 and 6, respectively in group II. Dysmenorrhea visual analog scale score decreased in both groups. Mean leiomyoma volume increased in both groups: by 25.7% with ormeloxifene versus 16.9% with COC; only grade 2 leiomyoma in group I reduced by 44%. One patient in group II with grade 2 leiomyoma discontinued treatment at 3\u00a0months. Seven patients (28%) developed ovarian cyst in group I with no other major adverse effect in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ormeloxifene with its convenient twice\u2010weekly dosage schedule was effective in treating AUB\u2010L, with 72% of patients responding to 6\u2010month treatment compared with 8% with COC, even though leiomyoma volume increased insignificantly with both ormeloxifene and COCs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13105","type":"journal-article","created":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T07:36:39Z","timestamp":1474356999000},"page":"1744-1752","source":"Crossref","is-referenced-by-count":14,"title":["Efficacy of ormeloxifene versus oral contraceptive in the management of abnormal uterine bleeding due to uterine leiomyoma"],"prefix":"10.1111","volume":"42","author":[{"given":"Alka","family":"Kriplani","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology 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