{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:12:55Z","timestamp":1779297175117,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T00:00:00Z","timestamp":1471305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Cervical intra\u2010epithelial neoplasia (CIN) is the precancerous stage of cervical cancer. Standard treatment for high\u2010grade CIN is conization of the cervix. The risk of preterm birth following conization has been discussed recently. In contrast, laser vaporization is believed not to affect perinatal outcome, but the long\u2010term effectiveness of each surgical procedure is still unclear. The aim of this prospective unmatched\u2010cohort study was therefore to compare virological and cytological clearance and recurrence risk between conization and vaporization for CIN3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subject consisted of CIN3 patients treated at the present hospital between 2007 to 2011 and followed up until December 2014. One hundred and one patients were treated with laser conization, and 137 with vaporization. The surgical procedure was selected on the basis of colposcopy, pathological grade and patient's hope for pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences in cure rate, human papilloma virus (HPV) clearance rate or recurrence rates between the conization and vaporization groups. Risk ratio of recurrence for each surgical procedure adjusted for age and HPV persistence status were analyzed on Cox proportional hazards modeling. Recurrence risk ratio for patients treated by vaporization was 6.21 (95%CI: 0.65\u201359.19; <jats:italic>P<\/jats:italic> = 0.111) compared with conization and there were no significant differences. No adverse pregnancy outcome was observed in the vaporization group compared with conization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Laser vaporization is useful for young patients with CIN3 who hope for pregnancy in the future.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13113","type":"journal-article","created":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T05:52:45Z","timestamp":1471326765000},"page":"1808-1813","source":"Crossref","is-referenced-by-count":12,"title":["Virological and cytological clearance in laser vaporization and conization for cervical intra\u2010epithelial neoplasia grade 3"],"prefix":"10.1111","volume":"42","author":[{"given":"Tasuku","family":"Mariya","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology NTT East Japan Sapporo Hospital  Sapporo Japan"},{"name":"Departments of Obstetrics and Gynecology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology NTT East Japan Sapporo Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanae","family":"Sogawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology NTT East Japan Sapporo Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riri","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology NTT East Japan Sapporo Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masae","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology NTT East Japan Sapporo Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akari","family":"Kawamata","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology NTT East Japan Sapporo Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumi","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology NTT East Japan Sapporo Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehito","family":"Nihei","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology NTT East Japan Sapporo Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Sonoda","sequence":"additional","affiliation":[{"name":"Public Health Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Saito","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-200006000-00018"},{"key":"e_1_2_7_3_1","volume-title":"WHO Guidelines for Screening and Treatment of Precancerous Lesions for Cervical Cancer Prevention","author":"World Health Organization","year":"2013"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021641"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.05.064"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.3.252"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0029-7844(98)00246-4","article-title":"A randomized clinical trial of cryotherapy, laser vaporization, and loop electrosurgical excision for treatment of squamous intraepithelial lesions of the cervix","volume":"92","author":"Follen Mitchell M","year":"1998","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.1999.781012.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2008.00834.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a1284"},{"key":"e_1_2_7_11_1","first-page":"1","article-title":"Fertility and early pregnancy outcomes after treatment for cervical intraepithelial neoplasia: Systematic review and meta\u2010analysis","volume":"6192","author":"Kyrgiou M","year":"2014","journal-title":"BMJ"},{"key":"e_1_2_7_12_1","first-page":"775","article-title":"Laser vaporization versus laser excision conization in the treatment of cervical intraepithelial neoplasia","volume":"73","author":"Partington CK","year":"1989","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00793-07"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010757.pub2"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68181-6"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp089"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70078-X"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001318.pub3"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22195"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.12.040"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.13113","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.13113","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.13113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T20:17:40Z","timestamp":1695500260000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.13113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,16]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1111\/jog.13113"],"URL":"https:\/\/doi.org\/10.1111\/jog.13113","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,16]]}}}