{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T10:09:49Z","timestamp":1772186989425,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T00:00:00Z","timestamp":1474329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the analytical and clinical effectiveness of cervicovaginal self\u2010sampling with a dry sampling device (Evalyn Brush) for high\u2010risk human papillomavirus (hr\u2010HPV) testing and detection of cervical disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study population consisted of 101 patients from a large gynecological outpatient clinic in Shanghai referred for abnormal cervical screening results and 101 women without cervical lesions. Self\u2010samples obtained in the clinic and physician\u2010collected cervical specimens (reference) were stored at \u221220 \u00b0C for 16\u201318 weeks and then transferred to 20 ml of ThinPrep medium and tested for hr\u2010HPV using a multiplex real time polymerase chain reaction assay. All women had a colposcopic examination with a Pap smear and directed or random biopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High risk\u2010HPV was detected in 92 patients (45.5%) with the self\u2010collected cervicovaginal specimens and in 93 (46.0%) with the physician\u2010collected cervical specimens, resulting in an agreement of 97.5% and a Kappa of 0.95 (95% confidence interval 0.91\u20130.99). Among all of the included women, 46 (22.8%) had cervical intraepithelial neoplasia grade 3 or worse (cervical intraepithelial neoplasia 3+). Hr\u2010HPV was found in 43 of these patients (93.5%) with self\u2010sampling and in 44 (95.7%) with the physician\u2010collected specimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Self\u2010collected dry cervicovaginal samples transferred to ThinPrep medium and tested for hr\u2010HPV using a clinically validated polymerase chain reaction assay showed very good agreement with physician\u2010collected cervical specimens and a very high hr\u2010HPV positivity rate for cervical intraepithelial neoplasia 3 +.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13132","type":"journal-article","created":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T08:46:55Z","timestamp":1474361215000},"page":"1839-1845","source":"Crossref","is-referenced-by-count":20,"title":["Excellent analytical and clinical performance of a dry self\u2010sampling device for human papillomavirus detection in an urban Chinese referral 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