{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:02:25Z","timestamp":1791874945196,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T00:00:00Z","timestamp":1477267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to compare 17\u2010alpha\u2010hydroxyprogesterone caproate (17OHP\u2010C) with vaginal progesterone suppository for the prevention of preterm birth in women with a sonographically short cervix and to evaluate the changes of the cervical length (CL) over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective randomized controlled trial, eligible patients were asymptomatic pregnant women with a sonographically short cervix. The participants in group 1 (<jats:italic>n<\/jats:italic> = 147) received vaginal progesterone suppositories at a dose of 400 mg daily and the women in group 2 (<jats:italic>n<\/jats:italic> = 150) received an i.m. dose of 250 mg 17OHP\u2010C once a week. Transvaginal sonography was repeated every 3 weeks until 36 gestational weeks or the occurrence of preterm labor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 304 singleton pregnant women between 16 and 24 gestational weeks with CL &lt; 25 mm were enrolled in our study. The rates of preterm birth were 10.4% in the progesterone group and 14% in the 17OHP\u2010C group: a difference that was not statistically significant (<jats:italic>P<\/jats:italic> = 0.416). Moreover, 264 participants underwent ultrasound examination five times and CL changes were studied for 15 weeks. The results showed that the CL changes over 15 weeks were statistically significant (<jats:italic>P<\/jats:italic> &lt; 0.001), but the method of intervention (progesterone\/17OHP\u2010C) had no significant effect on CL change (<jats:italic>P<\/jats:italic> = 0.64).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings showed that vaginal progesterone and 17OHP\u2010C had the same effect on the risk of preterm labor in asymptomatic women with a sonographically short cervix. We detected no significant difference between the effect of 17OHP\u2010C and vaginal progesterone on CL changes over time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13151","type":"journal-article","created":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T11:25:26Z","timestamp":1477308326000},"page":"57-64","source":"Crossref","is-referenced-by-count":12,"title":["17\u2010alpha\u2010hydroxyprogesterone caproate versus vaginal progesterone suppository for the prevention of preterm birth in women with a sonographically short cervix: A randomized controlled trial"],"prefix":"10.1111","volume":"43","author":[{"given":"Reihaneh","family":"Pirjani","sequence":"first","affiliation":[{"name":"Perinatology Division, Obstetrics and Gynecology Department, Arash Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Heidari","sequence":"additional","affiliation":[{"name":"School of Medicine Tehran University 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