{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:04:46Z","timestamp":1790107486834,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,12]],"date-time":"2016-11-12T00:00:00Z","timestamp":1478908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This retrospective cohort study evaluated the effectiveness of injury to the endometrium prior to the frozen\u2013thawed embryo transfer (FET) cycle in patients with repeated implantation failure (RIF) in our clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Included in this study were 173 patients, aged\u00a0\u2264\u00a041 years, who failed to become pregnant after repeating fair and\/or good embryo transfer more than twice between February 2012 and February 2015. The patients were divided into three groups: Group A (<jats:italic>n<\/jats:italic>\u00a0=\u00a038) underwent soft curettage to the endometrium twice, prior to the FET cycle; Group B (<jats:italic>n<\/jats:italic>\u00a0=\u00a045) underwent hysteroscopy prior to the FET cycle, with no significant factors, such as endometrial polyp; and Group C (<jats:italic>n<\/jats:italic> = 90) was the no\u2010treatment group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The clinical pregnancy rate per transfer was found to be statistically significant between Group A at 42.1% (16\/38) and Group C at 22.2% (20\/90). The crude and adjusted odds ratios (OR) were 2.55 and 2.49 (95% confidence intervals 1.13\u20135.78, <jats:italic>P<\/jats:italic> = 0.03 and 1.01\u20136.17, <jats:italic>P<\/jats:italic> = 0.048) respectively. Group B with only hysteroscopy had a higher pregnancy rate of 35.6% (16\/45) than Group C, but showed no statistical significance (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.103).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that injuring the endometrium has a positive effect on pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13182","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T13:42:38Z","timestamp":1479303758000},"page":"128-134","source":"Crossref","is-referenced-by-count":19,"title":["Injury to the endometrium prior to the frozen\u2013thawed embryo transfer cycle improves pregnancy rates in patients with repeated implantation failure"],"prefix":"10.1111","volume":"43","author":[{"given":"Emiko","family":"Kanazawa","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Kurume University School of Medicine  Fukuoka 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