{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T07:17:21Z","timestamp":1719904641781},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was the characterization of a new subtype of high\u2010grade cervical squamous intraepithelial lesion (HSIL) with enlarged cells containing bizarre nuclei: so\u2010called bizarre cell dysplasia (BCD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 29 cervical cone biopsy samples of this type of dysplasia were studied. Multi\u2010target polymerase chain reaction and <jats:italic>in situ<\/jats:italic> hybridization human papillomavirus (HPV) detection was performed in all cases. BCD was defined as a subtype of HSIL characterized by the presence of large dysplastic cells with abnormal, large pleomorphic nuclei or multinucleation causing nucleomegaly. This results in bizarre nuclear shapes. Bizarre cells are scattered throughout the whole thickness of the dysplastic squamous epithelium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The BCD lesions arise within the conventional\/classic high grade or \u201cbland\u201d type squamous dysplasia HSIL. Statistically they were significantly associated with HVP type 16. A significant association with other studied viruses (Herpes simplex virus [HSV]1, HSV2, Varicella zoster virus, Epstein\u2013Barr virus, cytomegalovirus, human herpesvirus 6, and human polyomaviruses BK and JC) was not confirmed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>BCD involves cytologically characteristic morphologic changes that are recognizable, but which may pose some risk of misdiagnosis as low\u2010grade squamous intraepithelial lesion due to the enlargement of dysplastic cells and multinucleation. Based on the unique histological, cytological and biological features of BCD including strong association with HPV 16 infection, we believe that this is a specific, and so far unrecognized variant of HSIL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13196","type":"journal-article","created":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T02:27:37Z","timestamp":1486002457000},"page":"345-351","source":"Crossref","is-referenced-by-count":4,"title":["Bizarre cell dysplasia of the cervix"],"prefix":"10.1111","volume":"43","author":[{"given":"Ondrej","family":"Ondi\u010d","sequence":"first","affiliation":[{"name":"Bioptick\u00e1 Laboratory  Pilsen Czech Republic"},{"name":"\u0160ikl's Department of Pathology Medical Faculty Hospital, Charles University  Pilsen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radoslav","family":"Ferko","sequence":"additional","affiliation":[{"name":"Bioptick\u00e1 Laboratory  Pilsen Czech Republic"},{"name":"\u0160ikl's Department of Pathology Medical Faculty Hospital, Charles University  Pilsen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Ka\u0161p\u00edrkov\u00e1","sequence":"additional","affiliation":[{"name":"Bioptick\u00e1 Laboratory  Pilsen Czech Republic"},{"name":"\u0160ikl's Department of Pathology Medical Faculty Hospital, Charles University  Pilsen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Mari\u00e1n","family":"\u0160vajdler","sequence":"additional","affiliation":[{"name":"Bioptick\u00e1 Laboratory  Pilsen Czech Republic"},{"name":"\u0160ikl's Department of Pathology Medical Faculty Hospital, Charles University  Pilsen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"R\u00fdchly","sequence":"additional","affiliation":[{"name":"Cytopathos  Bratislava Slovak Republic"},{"name":"Department of Pathology Slovak Medical University  Bratislava Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Talar\u010d\u00edk","sequence":"additional","affiliation":[{"name":"Cytopathos  Bratislava Slovak Republic"},{"name":"Department of Pathology Slovak Medical University  Bratislava Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u0159\u00ed","family":"Bouda","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Medical Faculty Hospital, Charles University  Pilsen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Michal","sequence":"additional","affiliation":[{"name":"\u0160ikl's Department of Pathology Medical Faculty Hospital, Charles University  Pilsen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"172","volume-title":"WHO Classification of 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