{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:26:52Z","timestamp":1784042812721,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T00:00:00Z","timestamp":1482105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to determine whether women with pregnancy\u2010induced antithrombin deficiency (PIATD) had higher risk of liver dysfunction in the absence of thrombocytopenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We carried out a retrospective observational study at five centers in all 129 women with incidentally found PIATD among 5249 maternities and 129 control women without PIATD matched for number of fetuses and gestational week at delivery. PIATD was diagnosed in women with antenatal antithrombin (AT) activities of \u226475% followed by a further decrease to \u226465% peripartum. Liver dysfunction was defined as serum aspartate aminotransferase &gt; \u200545 IU\/L concomitant with lactate dehydrogenase &gt; \u2005400 IU\/L. Thrombocytopenia was defined as platelet count &lt; 120 \u00d7 10<jats:sup>9<\/jats:sup>\/L.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thrombocytopenia (22% [28\/129] vs 5.4% [7\/129], <jats:italic>P<\/jats:italic> = \u20050.0001) and liver dysfunction (16% [20\/129] vs 0.0% [0\/129], <jats:italic>P<\/jats:italic> = \u20050.0000) occurred significantly more often in PIATD than in control women. Of the 20 women with liver dysfunction, 15 (75%) had PIATD, but not thrombocytopenia. Thus, even in the absence of thrombocytopenia, liver dysfunction occurred significantly more often in PIATD than in control women (15% [15\/101] vs 0.0% [0\/122], respectively, <jats:italic>P<\/jats:italic> = \u20050.0000). The relative risk (95% confidence interval) of liver dysfunction was 28.6 (1.64\u2013500) for women with AT activity of 60\u201365% and 52.4 (3.17\u2013865) for women with AT activity of &lt;60%, compared to women with AT activity \u226566%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PIATD can occur in the absence of thrombocytopenia and PIATD women had higher risk of liver dysfunction even in the absence of thrombocytopenia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13210","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T01:42:45Z","timestamp":1482198165000},"page":"257-264","source":"Crossref","is-referenced-by-count":8,"title":["Liver dysfunction in women with pregnancy\u2010induced antithrombin deficiency"],"prefix":"10.1111","volume":"43","author":[{"given":"Mamoru","family":"Morikawa","sequence":"first","affiliation":[{"name":"Department of Obstetrics Hokkaido University Graduate School of Medicine  Sapporo 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