{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:04:52Z","timestamp":1789639492780,"version":"4.0.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,12,27]],"date-time":"2016-12-27T00:00:00Z","timestamp":1482796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Recent investigations have demonstrated that athletes with high relaxin\u20102 levels have a high risk of anterior cruciate ligament injuries, while athletes taking oral contraceptives (OC) have low relaxin\u20102 levels. It has not yet been clarified whether taking OC reduces relaxin\u20102 levels. The purpose of this study was to investigate changes in relaxin\u20102 levels in athletes taking OC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Levels of relaxin\u20102, estradiol, progesterone, luteinizing hormone and follicle\u2010stimulating hormone were measured in serum samples (<jats:italic>n<\/jats:italic> = 183) from 106 elite female athletes. Five athletes with serum relaxin\u20102 concentrations &gt; 6 pg\/mL during the luteal phase were recruited to assess the effect of OC therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum relaxin\u20102 concentrations were significantly higher during the luteal phase (<jats:italic>n<\/jats:italic> = 57) than in the follicular phase (<jats:italic>n<\/jats:italic> = 72), or in athletes on OC therapy (<jats:italic>n<\/jats:italic> = 10) (<jats:italic>P<\/jats:italic> &lt; 0.001, <jats:italic>P<\/jats:italic> &lt; 0.001 and <jats:italic>P &lt;<\/jats:italic> 0.05, respectively). In the luteal phase, 36.8% (21\/57) of the athletes had relaxin levels &gt; 6 pg\/mL. In 23 athletes, serum relaxin\u20102 concentrations were measured during both the follicular and luteal phases, revealing that relaxin\u20102 levels were significantly higher in the luteal phase compared with the follicular phase. In 5 out of 23 athletes, serum relaxin\u20102 concentrations were &gt; 6 pg\/mL in the luteal phase and during the second cycle of OC therapy, relaxin\u20102 concentrations decreased dramatically to below the detection limit (0.26 pg\/mL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High serum relaxin\u20102 concentrations were only detected during the luteal phase. In athletes with high relaxin\u20102 concentrations during the luteal phase, OC therapy decreased serum relaxin\u20102 levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13226","type":"journal-article","created":{"date-parts":[[2016,12,27]],"date-time":"2016-12-27T13:29:16Z","timestamp":1482845356000},"page":"530-535","source":"Crossref","is-referenced-by-count":22,"title":["Oral contraceptive therapy reduces serum relaxin\u20102 in elite female athletes"],"prefix":"10.1111","volume":"43","author":[{"given":"Sayaka","family":"Nose\u2010Ogura","sequence":"first","affiliation":[{"name":"Japan Institute of Sports Sciences  Tokyo Japan"},{"name":"Department of Obstetrics and Gynecology University of Tokyo  Tokyo Japan"},{"name":"Department of Obstetrics and Gynecology University of Toyama  Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University 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