{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T08:13:06Z","timestamp":1696320786944},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,12,17]],"date-time":"2016-12-17T00:00:00Z","timestamp":1481932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This retrospective study was performed to determine the frequency of malformed infants born at a tertiary center in Hokkaido, Japan. The accuracy of prenatal diagnosis rates was also investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An observational study was performed using data of 1509 and 1743 newborn infants at a single center during two study periods, 2005\u20132009 (first) and 2010\u20132014 (second), respectively. Cases including minor anomalies (accessory auricle, nevus and fistula auris congenita) were not included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 274 and 569 malformations were identified in 191 and 337 newborn infants in the first and second study periods, respectively. The number of malformed infants increased significantly over time (13% [191\/1509] vs 19% [337\/1743], respectively; <jats:italic>P<\/jats:italic> &lt; 0.001), mainly as a result of an increase in cases of congenital heart disease (CHD), from 59 to 141 (31% [59\/191] vs 42% [141\/337] of all malformed infants in the first and second periods, respectively). The overall accurate prenatal diagnosis rate improved over time from 47% (128\/274) to 58% (329\/569) because of significant improvements in accurate prenatal diagnosis of CHD subtypes (23% [16\/70] vs 65% [151\/232] in the first and second periods, respectively, <jats:italic>P<\/jats:italic> &lt; 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The frequency of malformed newborns was higher in the tertiary center than in the general population. The increased number of cases with prenatal suspicion and diagnosis of CHD contributed to the increased frequency of malformed infants during the study period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13229","type":"journal-article","created":{"date-parts":[[2016,12,17]],"date-time":"2016-12-17T17:41:59Z","timestamp":1481996519000},"page":"505-510","source":"Crossref","is-referenced-by-count":1,"title":["Frequency of malformed infants in a tertiary center in Hokkaido, Japan over a period of 10 years"],"prefix":"10.1111","volume":"43","author":[{"given":"Itaru","family":"Hayasaka","sequence":"first","affiliation":[{"name":"Maternity and Perinatal Care Center Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutoshi","family":"Cho","sequence":"additional","affiliation":[{"name":"Maternity and Perinatal Care Center Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Uzuki","sequence":"additional","affiliation":[{"name":"Maternity and Perinatal Care Center Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Morioka","sequence":"additional","affiliation":[{"name":"Maternity and Perinatal Care Center Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuma","family":"Akimoto","sequence":"additional","affiliation":[{"name":"Maternity and Perinatal Care Center Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Maternity and Perinatal Care Center Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohta","family":"Takei","sequence":"additional","affiliation":[{"name":"Maternity and Perinatal Care Center Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Yamada","sequence":"additional","affiliation":[{"name":"Maternity and Perinatal Care Center Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoru","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Maternity and Perinatal Care Center Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yamada","sequence":"additional","affiliation":[{"name":"Maternity and Perinatal Care Center Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Ariga","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisanori","family":"Minakami","sequence":"additional","affiliation":[{"name":"Maternity and Perinatal Care Center Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12113"},{"key":"e_1_2_7_3_1","first-page":"1271","article-title":"Revised normative birthweight according to gestational week for Japanese infant","volume":"114","author":"Itabashi K","year":"2010","journal-title":"Nihon Shonika Gakkai Zasshi"},{"key":"e_1_2_7_4_1","unstructured":"International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR).Annual Report 2013. 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