{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T11:27:16Z","timestamp":1777116436616,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T00:00:00Z","timestamp":1485388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the predictive value of blastocoele re\u2010expansion time in clinical pregnancy outcome in vitrified\u2013warmed cycles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on 468 single vitrified\u2013thawed blastocyst transfer cycles (in patients aged &lt;38 years) carried out from January 2012 through December 2012, at the Reproductive Medicine Center, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, were analyzed. Vitrified\u2013warmed blastocysts were divided into three groups according to blastocoele re\u2010expansion time: group A, &lt;1 h; group B, 1\u20132 h; and group C, &gt;2 h, and the clinical pregnancy outcomes (i.e. live birth rate, miscarriage rate and occurrence of singleton pregnancies) compared between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant differences were observed in the implantation\/clinical pregnancy rate between groups A, B and C (70.10%, 51.76% and 28.74%, respectively, <jats:italic>P<\/jats:italic> &lt; 0.01). There was a significant linear decline in this rate with increasing blastocyst re\u2010expansion time. The rate of miscarriage also tended to increase with increasing blastocyst re\u2010expansion time, but the difference was not statistically significant (<jats:italic>P<\/jats:italic> &gt; 0.05). Of the pregnant patients, no significant difference was observed in the rates of monozygotic twins and ectopic pregnancy between the three groups. For the newborns, similar live birth, low\u2010birthweight and premature delivery rates were observed between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Timing of blastocoele re\u2010expansion in vitrified\u2013warmed cycles is a strong predictor of clinical pregnancy outcome. The faster the re\u2010expansion of the blastocoele, the higher the developmental potential of the blastocysts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13257","type":"journal-article","created":{"date-parts":[[2017,1,27]],"date-time":"2017-01-27T04:57:32Z","timestamp":1485493052000},"page":"689-695","source":"Crossref","is-referenced-by-count":20,"title":["Blastocoele re\u2010expansion time in vitrified\u2013warmed cycles is a strong predictor of clinical pregnancy outcome"],"prefix":"10.1111","volume":"43","author":[{"given":"Ruoyun","family":"Lin","sequence":"first","affiliation":[{"name":"Reproductive Medicine center, Maternal and Child Health Hospital Obstetrics and Gynecology Hospital of Guangxi Zhuang Autonomous Region  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guixue","family":"Feng","sequence":"additional","affiliation":[{"name":"Reproductive Medicine center, Maternal and Child Health Hospital Obstetrics and Gynecology Hospital of Guangxi 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