{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:42:38Z","timestamp":1780530158742,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T00:00:00Z","timestamp":1492473600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to assess the accuracy of self\u2010collected vaginal samples compared with physician\u2010collected cervical samples for high\u2010risk human papillomavirus (HPV) testing in Japanese women with abnormal cervical cytology. We also assessed the acceptability of self\u2010collected HPV (sHPV) testing using a questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women aged 20\u201369 years (<jats:italic>n<\/jats:italic> = 136) attending Yokohama City University Hospital because of abnormal cervical cytology between April 2014 and January 2015 were enrolled in this study. Cervical samples for conventional cytology and physician\u2010collected HPV (pHPV) testing were obtained before colposcopic examination. After this examination, patients were asked to provide a self\u2010sampled vaginal specimen (sHPV) at home, some time between the following day and the next week and to complete a self\u2010sampling acceptability questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall positive rates of HPV detection with pHPV and sHPV testing were 61.0% (83\/136) and 40.4% (55\/136), respectively (<jats:italic>P &lt;<\/jats:italic> 0.001). sHPV testing had a lower sensitivity compared to pHPV for detection of cervical intraepithelial neoplasia (CIN)2 or worse (CIN2+: 59.4% vs 100%, <jats:italic>P<\/jats:italic> &lt; 0.001; CIN3: 66.7% vs 100%, <jats:italic>P<\/jats:italic> = 0.248). There were no statistically significant differences in the sensitivity to detect CIN3 among pHPV testing, sHPV testing, and cytology. The self\u2010collecting device had good acceptability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>sHPV testing is a possible technique with which to improve poor cervical cancer screening uptake rates in Japan; however, the sensitivity to detect CIN2+ lesions must improve <jats:styled-content>before it can be a substitute for<\/jats:styled-content> conventional cytology or pHPV testing. Further large\u2010scale acceptability studies involving non\u2010responders are <jats:styled-content>also<\/jats:styled-content> needed before practical application.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13258","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T17:55:44Z","timestamp":1492538144000},"page":"710-717","source":"Crossref","is-referenced-by-count":19,"title":["Accuracy of self\u2010collected human papillomavirus samples from Japanese women with abnormal cervical cytology"],"prefix":"10.1111","volume":"43","author":[{"given":"Kawano\u2010Yashiro","family":"Aiko","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Yokohama City University Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoki","family":"Yoko","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yokohama City University Hospital  Yokohama Japan"},{"name":"Department of Obstetrics, Gynecology and Molecular Reproductive Science Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oba Mari","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asano","family":"Ryoko","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yokohama City University Hospital  Yokohama Japan"},{"name":"Department of Obstetrics, Gynecology and Molecular Reproductive Science Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maruyama","family":"Yasuyo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yokohama City University Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asai\u2010Sato","family":"Mikiko","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yokohama City University Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamanaka","family":"Takeharu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirahara","family":"Fumiki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yokohama City University Hospital  Yokohama Japan"},{"name":"Department of Obstetrics, Gynecology and Molecular Reproductive Science Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyagi","family":"Etsuko","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yokohama City University Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,18]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"IARC Handbooks of Cancer Prevention","author":"IARC Working Group on the Evaluation of Cancer Preventive Strategies","year":"2005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2015.08.001"},{"key":"e_1_2_7_4_1","unstructured":"Ministry of Health Labour and Welfare. 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