{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T07:47:18Z","timestamp":1694936838865},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T00:00:00Z","timestamp":1485993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acquired hemophilia A (AHA) is a serious and rare complication of pregnancy, caused by autoantibodies to coagulation factor VIII after delivery. We here report the case of a 36\u2010year\u2010old primigravida woman who developed AHA following chorioamnionitis\u2010caused miscarriage in the second trimester. Thirteen days after abortion, sudden, massive vaginal bleeding occurred with marked prolongation of activated partial thromboplastin time (APTT) in the absence of other abnormal coagulation data. Sequential transfusion of fresh frozen plasma did not achieve normalization of APTT. Further examination confirmed reduction of coagulation factor VIII and the presence of its inhibitor, leading to the final diagnosis of AHA. The patient was effectively treated with bypassing agents (activated prothrombin complex concentrate and recombinant activated factor VII) and immunosuppressive therapy. Fifteen months after remission, the patient became pregnant and successfully achieved term delivery with no signs of recurrence. This case illustrates that AHA should be considered in the occurrence of plasma transfusion\u2010uncontrolled severe bleeding after delivery.<\/jats:p>","DOI":"10.1111\/jog.13270","type":"journal-article","created":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T09:45:48Z","timestamp":1486028748000},"page":"763-767","source":"Crossref","is-referenced-by-count":4,"title":["Acquired hemophilia A manifesting as plasma transfusion\u2010uncontrolled severe bleeding 2 weeks after chorioamnionitis\u2010induced abortion"],"prefix":"10.1111","volume":"43","author":[{"given":"Ayumi","family":"Matsuoka","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ishikawa Medical Center for Maternal and Child Health Ishikawa Prefectural Central Hospital  Kanazawa Japan"},{"name":"Department of Obstetrics and Gynecology Kanazawa University Graduate School of Medical Science  Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromasa","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ishikawa Medical Center for Maternal and Child Health Ishikawa Prefectural Central Hospital  Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiharu","family":"Sugimori","sequence":"additional","affiliation":[{"name":"Department of Hematology Ishikawa Prefectural Central Hospital  Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Hirabuki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ishikawa Medical Center for Maternal and Child Health Ishikawa Prefectural Central Hospital  Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Hoshiba","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ishikawa Medical Center for Maternal and Child Health Ishikawa Prefectural Central Hospital  Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanazawa University Graduate School of Medical Science  Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-196105000-00002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-029850"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2012.03469.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1650169"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/107602960000600206"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1351-8216.2003.00814.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.12.040194.005015"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2012.171"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202698"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-200012000-00003"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1978.tb02434.x"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.13270","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.13270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T19:50:15Z","timestamp":1694893815000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.13270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,2]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/jog.13270"],"URL":"https:\/\/doi.org\/10.1111\/jog.13270","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,2]]}}}