{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T19:19:46Z","timestamp":1788808786333,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T00:00:00Z","timestamp":1492560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We hypothesized that feeling mucosal dryness in one body region and the skin may be associated with dryness in other regions and that there are common background factors for dryness. In an earlier web\u2010based survey, we reported prevalence figures of dry eyes, nose, mouth, skin, and vagina. In the present study, additional analyses were made to investigate the factors associated with dryness in each region, and simultaneous dryness in multiple regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A web\u2010based questionnaire was completed by 310 Japanese women. The questions included dryness of the eyes, nose, mouth, vagina, and skin. Menopausal and other symptoms were also addressed. Multiple logistic regression modeling was performed to identify factors associated with dryness in each region and in multiple dry regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dry eyes were associated with dryness in the nose and with headache; dry nose was associated with dryness in the vagina and eyes; dry mouth was associated with sticky mouth symptom and dryness of the nose; dry skin was associated with use of xerogenic medications and vaginal discharge; and dryness of the vagina was associated with vaginal itchiness and dry nose. Vaginal discharge (odds ratio, 9.64; 95% confidence interval, 3.15\u201329.51) and sticky mouth (odds ratio, 6.35; 95% confidence interval, 1.29\u201331.29) were further associated with dryness in multiple regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present results confirmed our study hypothesis by showing that dryness in one region was clearly associated with that in another or in multiple regions. The result implies the need for holistic diagnosis and counseling for patients with dryness complaints.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13290","type":"journal-article","created":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T12:50:20Z","timestamp":1492606220000},"page":"880-886","source":"Crossref","is-referenced-by-count":8,"title":["Factors associated with mucosal dryness in multiple regions and skin: A web\u2010based study in women"],"prefix":"10.1111","volume":"43","author":[{"given":"Kayoko","family":"Ito","sequence":"first","affiliation":[{"name":"Oral Rehabilitation Niigata University Medical and Dental Hospital  Niigata City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Takamatsu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tokyo Dental College Ichikawa General Hospital  Ichikawa City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaname","family":"Nohno","sequence":"additional","affiliation":[{"name":"Division of Preventive Dentistry Niigata University Graduate School of Medical and Dental Sciences  Niigata City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aki","family":"Sugano","sequence":"additional","affiliation":[{"name":"Tokyo Dental College School of Dental Hygiene  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saori","family":"Funayama","sequence":"additional","affiliation":[{"name":"Oral Rehabilitation Niigata University Medical and Dental Hospital  Niigata City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouji","family":"Katsura","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Radiology, Surgical care Niigata University Medical and Dental Hospital  Niigata City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Division of Preventive Dentistry Niigata University Graduate School of Medical and Dental Sciences  Niigata City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tokyo Dental College Ichikawa General Hospital  Ichikawa City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jukka H.","family":"Meurman","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Inoue","sequence":"additional","affiliation":[{"name":"Division of Dysphagia Rehabilitation Niigata University Graduate School of Medical and Dental Sciences  Niigata City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(03)00218-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-2358.2005.00058.x"},{"key":"e_1_2_6_4_1","first-page":"1","article-title":"Xerostomia: Prevalence and pharmacotherapy. 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