{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T03:36:59Z","timestamp":1781581019354,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T00:00:00Z","timestamp":1495152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to examine the role of hereditary thrombophilia in the development of fetal growth retardation (FGR) in the population of Central Russia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The case\u2013control study sample included 497 women in the third trimester of pregnancy recruited during 2009\u20132013. The participants were enrolled into two groups: patients with FGR (<jats:italic>n<\/jats:italic> = 250) and controls without FGR (<jats:italic>n<\/jats:italic> = 247). The participants were genotyped for four genetic markers of hereditary thrombophilia: factor V Leiden (<jats:italic>G &gt; A FV<\/jats:italic>, rs6025), prothrombin (<jats:italic>G &gt; A FII<\/jats:italic>, rs1799963), factor VII (<jats:italic>G &gt; A FVII<\/jats:italic>, rs6046), and fibrinogen (<jats:italic>G &gt; A FI<\/jats:italic>, rs1800790).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The genetic factors for an increased risk of FGR were allele <jats:italic>G<\/jats:italic> of rs6046 (odds ratio [OR]\u00a0=\u00a02.34) and genotype <jats:italic>GG<\/jats:italic> of rs6046 (OR =\u00a02.64), whereas genotype <jats:italic>GA<\/jats:italic> of rs6046 had the protective value (OR\u00a0=\u00a00.42). A combination of alleles <jats:italic>G<\/jats:italic> of rs1799963, <jats:italic>A<\/jats:italic> of rs6046, and <jats:italic>G<\/jats:italic> of rs1800790 (OR\u00a0=\u00a00.31) reduces the risk of FGR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Polymorphism rs6046 of the <jats:italic>FVII<\/jats:italic> gene is associated with the development of FGR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13329","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T15:00:16Z","timestamp":1495551616000},"page":"1139-1144","source":"Crossref","is-referenced-by-count":39,"title":["Genetic markers for inherited thrombophilia are associated with fetal growth retardation in the population of Central Russia"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5429-6666","authenticated-orcid":false,"given":"Evgeny","family":"Reshetnikov","sequence":"first","affiliation":[{"name":"Department of Medical 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