{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:02:42Z","timestamp":1792112562816,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T00:00:00Z","timestamp":1492560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"This study was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture of Japan","award":["25462546"],"award-info":[{"award-number":["25462546"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study was performed to determine the associations between serum placental growth factor (PlGF) and soluble fms\u2010like tyrosine kinase 1 (sFlt\u20101) levels at mid\u2010gestation with the risk of small\u2010for\u2010gestational\u2010age (SGA) neonates born at gestational week (GW) \u2265 36 in healthy women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PlGF and sFlt\u20101 concentrations were determined at GW 24\u201327 in 183 women with births at GW\u00a0\u2265\u00a036, but without gestational diabetes mellitus and hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen (7.1%) SGA neonates were born. Median (range) GW at blood sampling was similar between women with and without SGA (25 [24\u201325] and 24 [24\u201327], respectively, <jats:italic>P<\/jats:italic> = 0.671). Pre\u2010pregnancy body mass index (BMI) and PlGF levels were significantly lower in women with than without SGA, while sFlt\u20101 levels and sFlt\u20101\u00a0:\u00a0PlGF ratio (sFlt\u20101\/PlGF) did not differ significantly between the two groups. PlGF and sFlt\u20101\/PlGF, but not BMI or sFlt\u20101, showed significant correlations with birthweight <jats:italic>z<\/jats:italic>\u2010score; the correlation was positive for PlGF and negative for sFlt\u20101\/PlGF. Women with PlGF level\u00a0&lt; 10th percentile and those with sFlt\u20101\/PlGF level\u00a0&gt; 90th percentile showed significantly increased risk of SGA compared to those with respective counterpart characteristics; relative risk was 3.8 (95% confidence interval, 1.3\u201311.3; 21% [4\/19] vs 5.5% [9\/164]) for PlGF and 7.9 (95% confidence interval, 3.0\u201320.8, 33.3% [6\/18] vs 4.2% [7\/165]) for sFlt\u20101\/PlGF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maternal PlGF and sFlt\u20101\/PlGF determined during GW 24\u201327 were associated with the risk of SGA neonates born at GW\u2005\u2265 36, even in women with uncomplicated pregnancies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13340","type":"journal-article","created":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T13:47:14Z","timestamp":1492609634000},"page":"1152-1158","source":"Crossref","is-referenced-by-count":8,"title":["Serum placental growth factor and soluble fms\u2010like 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