{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:28:01Z","timestamp":1740126481519,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T00:00:00Z","timestamp":1495152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Health and Labor Sciences Research Grants of Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study investigated the feasibility and safety of fetoscopic laser photocoagulation (FLP) for amniotic fluid discordance (AFD) bordering on twin\u2013twin transfusion syndrome (TTTS) with an absent or reverse end\u2010diastolic velocity (AREDV) in the umbilical artery (UA), and evaluated the perinatal and long\u2010term outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective intervention study was performed between 20\u00a0+\u00a00 and 25\u00a0+\u00a06\u00a0weeks of gestation (UMIN000004165). AFD bordering on TTTS was defined as maximum vertical pocket (MVP) of amniotic fluid in one twin's sac \u22643\u00a0cm and amniotic fluid MVP in the other twin's sac \u22657\u00a0cm excluding TTTS. Neurodevelopmental outcome was evaluated at 6\u00a0months and at 3\u00a0years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven women were treated without complications between September 2010 and July 2011. In all cases amnioinfusion was required, with a median surgical time of 70\u00a0min. There were nine cases of selective intrauterine growth restriction in which the growth discordant rate was &gt;25%. The survival rates of the donor and recipient twins were 27.3% (3\/11) and 100% (11\/11), respectively. None of the surviving donor twins and two of the 11 recipient twins had hemiplegia at 6\u00a0months of age. One additional recipient twin had developmental delay at 3\u00a0years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fetoscopic laser photocoagulation for AFD bordering on TTTS with AREDV in the UA was feasible without complications but frequently resulted in donor twin death and a high survival rate of the recipient twin, albeit with neurodevelopmental abnormalities in some cases. FLP does not seem to be a promising treatment option for AFD bordering on TTTS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13349","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T14:49:19Z","timestamp":1495550959000},"page":"1256-1262","source":"Crossref","is-referenced-by-count":4,"title":["Fetoscopic laser photocoagulation for amniotic fluid discordance bordering on twin\u2013twin transfusion syndrome: Feasibility, perinatal and long\u2010term outcomes"],"prefix":"10.1111","volume":"43","author":[{"given":"Katsusuke","family":"Ozawa","sequence":"first","affiliation":[{"name":"Center of Maternal\u2013Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rika","family":"Sugibayashi","sequence":"additional","affiliation":[{"name":"Center of Maternal\u2013Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Wada","sequence":"additional","affiliation":[{"name":"Center of Maternal\u2013Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Sumie","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Fukuoka Children's Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine Osaka Medical Center and Research Institute for Maternal and Child Health  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Nakata","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Toho University Omori Medical Center  Tokyo 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